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LPS-stimulated PMN activation and proinflammatory mediator synthesis is downregulated by phosphodiesterase inhibition: Role of pentoxyfylline

  • Raul Coimbra
  • , William Loomis
  • , Heidi Melbostad
  • , Maria Tobar
  • , Rafael D. Porcides
  • , David B. Hoyt

Research output: Contribution to journal › Article › peer-review

Original languageEnglish
Pages (from-to)1157-1163
Number of pages7
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume57
Issue number6
DOIs
StatePublished - Dec 2004
Externally publishedYes

ASJC Scopus Subject Areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Keywords

  • Adhesion molecule
  • Inflammatory response
  • LPS
  • Neutrophil
  • Oxidative burst
  • PMN
  • Pentoxifylline
  • Sepsis
  • TNF-α
  • Sepsis/drug therapy
  • Down-Regulation
  • Humans
  • Pentoxifylline/pharmacology
  • Tumor Necrosis Factor-alpha/biosynthesis
  • Cell Adhesion Molecules/biosynthesis
  • Respiratory Burst/drug effects
  • Lipopolysaccharides
  • Inflammation Mediators/blood
  • Analysis of Variance
  • CD11b Antigen/biosynthesis
  • In Vitro Techniques
  • Neutrophil Activation/drug effects
  • Phosphodiesterase Inhibitors/pharmacology

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