@article{f2f3535f7246421f8f6c6a27895dd95c,
title = "Low-dose γ-rays modify CD4+ T cell signalling response to simulated solar particle event protons in a mouse model",
keywords = "T lymphocytes, cytokines, particle radiation, signalling pathways, solar flare, Signal Transduction/radiation effects, Humans, p38 Mitogen-Activated Protein Kinases/metabolism, Cell Survival/radiation effects, Protons/adverse effects, Female, Models, Animal, Lymphocyte Activation/radiation effects, Space Simulation, Gamma Rays/adverse effects, JNK Mitogen-Activated Protein Kinases/metabolism, Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism, Mice, Inbred C57BL, Animals, Solar Activity, CD4-Positive T-Lymphocytes/immunology, ZAP-70 Protein-Tyrosine Kinase/metabolism, Mice, NF-kappa B/metabolism, Dose-Response Relationship, Radiation, Cytokines/biosynthesis",
author = "Asma Rizvi and Pecaut, \{Michael J.\} and Slater, \{James M.\} and Shruti Subramaniam and Gridley, \{Daila S.\}",
note = "Funding Information: The authors thank Melba L. Andres and Steve Rightnar for assistance in biological assays and g-radiation dosimetry. Also, the expert advice and assistance of Dr George B. Coutrakon, Peter Koss, and engineers at Optivus Technology, Inc. needed for execution of sSPE protons is greatly appreciated. We would also like to thank Ingenuity Pathways Analysis (Ingenuity{\textregistered} Systems, www.ingenuity.com) from which we derived information to design the survival/signalling pathway interactions (Figure 7). This study was supported by the Low Dose Radiation Research Program, Office of Science, U.S. Department of Energy Grant No. DE-FG02-05ER64098, NASA grant NNJ06HD78A, and the LLUMC Department of Radiation Medicine.",
year = "2011",
month = jan,
doi = "10.3109/09553002.2010.518206",
language = "English",
volume = "87",
pages = "24--35",
journal = "International Journal of Radiation Biology",
issn = "0955-3002",
number = "1",
}