@article{ff95371a33124d3b84e84230f483d729,
title = "Loss of neuronal cell cycle control as a mechanism of neurodegeneration in the presenilin-1 alzheimer's disease brain",
keywords = "Alzheimer's disease, Apoptosis, Cell cycle, Presenilin, β-catenin, Humans, Middle Aged, Male, Presenilin-1/metabolism, Neurons/drug effects, Cell Cycle/drug effects, Enzyme Inhibitors/pharmacology, Brain/drug effects, beta Catenin/metabolism, Aged, 80 and over, Nerve Degeneration/pathology, Adult, Female, Amyloid Precursor Protein Secretases/antagonists \& inhibitors, Mutant Proteins/metabolism, Cyclin D1/metabolism, Mutation/genetics, Apoptosis/drug effects, Animals, Aged, Mice, Quercetin/pharmacology, Alzheimer Disease/metabolism",
author = "Bilal Malik and Antonio Currais and Ana Andres and Christopher Towlson and Didier Pitsi and Ana Nunes and Michael Niblock and Jonathan Cooper and Tibor Hortob{\'a}gyi and Salvador Soriano",
note = "Funding Information: 71, male). AD cases {\textcopyright}2008 LANDES BIOSCIENCEFor immunohistochemistry analysis, 7 μm microtome brain autopsy samples; Dr Brian Sopher for the use of presenilin-1 (n = 5, ages 55, female; 86, male; 68, female; 40, male; Council (G9626876) for the use of familial Alzheimer{\textquoteright}s disease sections were cut from paraformaldehyde-fixed paraffin-embedded KIM146V mice; Dr Frank Hirth for his insightful discussion of this human temporal lobe containing the hippocampal formation and manuscript; Mrs Mavis Kibble for her expert technical help with the mounted on glass slides coated with 3-aminopropyltriethoxysilane immunohistochemistry experiments on human samples. (APES). Sections were dewaxed by xylene, rehydrated in graded alco-This work was funded by the Alzheimer{\textquoteright}s Association, USA hols, and endogenous peroxydase activity was blocked by H2O2 in (IIRG-02-3892 to SS) and Alzheimer{\textquoteright}s Research Trust, UK (EG methanol. Standard antigen retrieval treatment was then carried out 2003B to SS).",
year = "2008",
month = mar,
day = "1",
doi = "10.4161/cc.7.5.5427",
language = "English",
volume = "7",
pages = "637--646",
journal = "Cell Cycle",
issn = "1538-4101",
number = "5",
}