Life in a diverse oral community - Strategies for oxidative stress survival

Leroy G. Henry; Marie Claire Boutrin; A. Wilson Aruni; Antonette Robles; Alexia Ximinies; Hansel M. Fletcher

doi:10.1016/j.job.2014.03.001

Life in a diverse oral community - Strategies for oxidative stress survival

Leroy G. Henry, Marie Claire Boutrin, A. Wilson Aruni, Antonette Robles, Alexia Ximinies, Hansel M. Fletcher

Research output: Contribution to journal › Review article › peer-review

Abstract

Background: While the oral cavity harbors more than 680 bacterial species, the interaction and association of selected bacterial species play a role in periodontal diseases. Bacterial species including Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, a consortium previously designated as the 'red complex' is now being expanded to include other new emerging pathogens that are significantly associated with periodontal disease. Highlight: In addition to novel mechanisms for oxidative resistance of individual species, community dynamics may lead to an overall strategy for survival in the inflammatory environment of the periodontal pocket. Complex systems controlled by response regulators protect against oxidative and nitrosative stress. Conclusion: The combination of these multifaceted strategies would provide a comprehensive defense and support system against the repetitive host immune response to promote microbial persistence and disease.

Original language	English
Pages (from-to)	63-71
Number of pages	9
Journal	Journal of Oral Biosciences
Volume	56
Issue number	2
DOIs	https://doi.org/10.1016/j.job.2014.03.001
State	Published - May 2014

ASJC Scopus Subject Areas

Medicine (miscellaneous)
General Dentistry
General Biochemistry,Genetics and Molecular Biology

Keywords

Filifactor alocis
Oral microbiome
Oxidative stress
Porphyromonas gingivalis
Red complex

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10.1016/j.job.2014.03.001

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title = "Life in a diverse oral community - Strategies for oxidative stress survival",

abstract = "Background: While the oral cavity harbors more than 680 bacterial species, the interaction and association of selected bacterial species play a role in periodontal diseases. Bacterial species including Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, a consortium previously designated as the 'red complex' is now being expanded to include other new emerging pathogens that are significantly associated with periodontal disease. Highlight: In addition to novel mechanisms for oxidative resistance of individual species, community dynamics may lead to an overall strategy for survival in the inflammatory environment of the periodontal pocket. Complex systems controlled by response regulators protect against oxidative and nitrosative stress. Conclusion: The combination of these multifaceted strategies would provide a comprehensive defense and support system against the repetitive host immune response to promote microbial persistence and disease.",

keywords = "Filifactor alocis, Oral microbiome, Oxidative stress, Porphyromonas gingivalis, Red complex",

author = "Henry, {Leroy G.} and Boutrin, {Marie Claire} and Aruni, {A. Wilson} and Antonette Robles and Alexia Ximinies and Fletcher, {Hansel M.}",

note = "Funding Information: This work was supported by Loma Linda University and Public Health Services Grants DE13664 , DE019730 , DE019730 04S1 , DE022508 , and DE022724 from NIDCR (to H.M.F). ",

year = "2014",

month = may,

doi = "10.1016/j.job.2014.03.001",

language = "English",

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T1 - Life in a diverse oral community - Strategies for oxidative stress survival

AU - Henry, Leroy G.

AU - Boutrin, Marie Claire

AU - Aruni, A. Wilson

AU - Robles, Antonette

AU - Ximinies, Alexia

AU - Fletcher, Hansel M.

N1 - Funding Information: This work was supported by Loma Linda University and Public Health Services Grants DE13664 , DE019730 , DE019730 04S1 , DE022508 , and DE022724 from NIDCR (to H.M.F).

PY - 2014/5

Y1 - 2014/5

N2 - Background: While the oral cavity harbors more than 680 bacterial species, the interaction and association of selected bacterial species play a role in periodontal diseases. Bacterial species including Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, a consortium previously designated as the 'red complex' is now being expanded to include other new emerging pathogens that are significantly associated with periodontal disease. Highlight: In addition to novel mechanisms for oxidative resistance of individual species, community dynamics may lead to an overall strategy for survival in the inflammatory environment of the periodontal pocket. Complex systems controlled by response regulators protect against oxidative and nitrosative stress. Conclusion: The combination of these multifaceted strategies would provide a comprehensive defense and support system against the repetitive host immune response to promote microbial persistence and disease.

AB - Background: While the oral cavity harbors more than 680 bacterial species, the interaction and association of selected bacterial species play a role in periodontal diseases. Bacterial species including Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, a consortium previously designated as the 'red complex' is now being expanded to include other new emerging pathogens that are significantly associated with periodontal disease. Highlight: In addition to novel mechanisms for oxidative resistance of individual species, community dynamics may lead to an overall strategy for survival in the inflammatory environment of the periodontal pocket. Complex systems controlled by response regulators protect against oxidative and nitrosative stress. Conclusion: The combination of these multifaceted strategies would provide a comprehensive defense and support system against the repetitive host immune response to promote microbial persistence and disease.

KW - Filifactor alocis

KW - Oral microbiome

KW - Oxidative stress

KW - Porphyromonas gingivalis

KW - Red complex

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ER -

Life in a diverse oral community - Strategies for oxidative stress survival

Abstract

ASJC Scopus Subject Areas

Keywords

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