Abstract
The expression of kidney injury molecule-1 (KIM-1), a very promising sensitive and specific urinary biomarker for acute renal injury, is markedly upregulated in injured and regenerating renal proximal tubular epithelial cells following ischemic or toxic insults, suggesting a possible role for this molecule in renal repair process. In the present study, we report that expression of KIM-1 facilitates renal tubular epithelial cell repair by promoting cell migration and proliferation. KIM-1 expression also enhances ERK MAPK activation, and the modulatory effect of KIM-1 on cellular repair process is likely mediated via ERK MAPK signaling pathway.
| Original language | English |
|---|---|
| Pages (from-to) | 109-116 |
| Number of pages | 8 |
| Journal | Molecular and Cellular Biochemistry |
| Volume | 416 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - May 1 2016 |
ASJC Scopus Subject Areas
- Molecular Biology
- Clinical Biochemistry
- Cell Biology
Keywords
- Cell migration
- Cell proliferation
- Cellular repair
- ERK MAPK
- Kidney injury molecule-1 (KIM-1)
- Cell Line
- Epithelial Cells/metabolism
- Cell Proliferation
- Hepatitis A Virus Cellular Receptor 1/genetics
- Humans
- Kidney Tubules, Proximal/metabolism
- MAP Kinase Signaling System
- Cell Movement