TY - JOUR
T1 - Ischemic preconditioning of the lower extremity attenuates the normal hypoxic increase in pulmonary artery systolic pressure
AU - Foster, Gary P.
AU - Westerdahl, Daniel E.
AU - Foster, Laura A.
AU - Hsu, Jeffrey V.
AU - Anholm, James D.
N1 - Respir Physiol Neurobiol. 2011 Dec 15;179(2-3):248-53. doi: 10.1016/j.resp.2011.09.001. Epub 2011 Sep 9. Randomized Controlled Trial
PY - 2011/12/15
Y1 - 2011/12/15
N2 - Ischemic pre-condition of an extremity (IPC) induces effects on local and remote tissues that are protective against ischemic injury. To test the effects of IPC on the normal hypoxic increase in pulmonary pressures and exercise performance, 8 amateur cyclists were evaluated under normoxia and hypoxia (13% F IO 2) in a randomized cross-over trial. IPC was induced using an arterial occlusive cuff to one thigh for 5min followed by deflation for 5min for 4 cycles. In the control condition, the resting pulmonary artery systolic pressure (PASP) increased from a normoxic value of 25.6±2.3mmHg to 41.8±7.2mmHg following 90min of hypoxia. In the IPC condition, the PASP increased to only 32.4±3.1mmHg following hypoxia, representing a 72.8% attenuation (p=0.003). No significant difference was detected in cycle ergometer time trial duration between control and IPC conditions with either normoxia or hypoxia. IPC administered prior to hypoxic exposure was associated with profound attenuation of the normal hypoxic increase of pulmonary artery systolic pressure.
AB - Ischemic pre-condition of an extremity (IPC) induces effects on local and remote tissues that are protective against ischemic injury. To test the effects of IPC on the normal hypoxic increase in pulmonary pressures and exercise performance, 8 amateur cyclists were evaluated under normoxia and hypoxia (13% F IO 2) in a randomized cross-over trial. IPC was induced using an arterial occlusive cuff to one thigh for 5min followed by deflation for 5min for 4 cycles. In the control condition, the resting pulmonary artery systolic pressure (PASP) increased from a normoxic value of 25.6±2.3mmHg to 41.8±7.2mmHg following 90min of hypoxia. In the IPC condition, the PASP increased to only 32.4±3.1mmHg following hypoxia, representing a 72.8% attenuation (p=0.003). No significant difference was detected in cycle ergometer time trial duration between control and IPC conditions with either normoxia or hypoxia. IPC administered prior to hypoxic exposure was associated with profound attenuation of the normal hypoxic increase of pulmonary artery systolic pressure.
KW - Hypoxia
KW - Ischemic pre-conditioning
KW - Pulmonary pressure
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U2 - 10.1016/j.resp.2011.09.001
DO - 10.1016/j.resp.2011.09.001
M3 - Article
C2 - 21924386
SN - 1569-9048
VL - 179
SP - 248
EP - 253
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 2-3
ER -