Inhibition of EZH2 (Enhancer of Zeste Homolog 2) Attenuates Neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB (Trimethylation of Histone 3 Lysine 27/Suppressor of Cytokine Signaling 3/Tumor Necrosis Factor Receptor Family 6/Nuclear Factor-κB) in a Rat Model of Subarachnoid Hemorrhage

Yujie Luo; Yuanjian Fang; Ruiqing Kang; Cameron Lenahan; Marcin Gamdzyk; Zeyu Zhang; Takeshi Okada; Jiping Tang; Sheng Chen; John H. Zhang

doi:10.1161/STROKEAHA.120.029951

Inhibition of EZH2 (Enhancer of Zeste Homolog 2) Attenuates Neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB (Trimethylation of Histone 3 Lysine 27/Suppressor of Cytokine Signaling 3/Tumor Necrosis Factor Receptor Family 6/Nuclear Factor-κB) in a Rat Model of Subarachnoid Hemorrhage

Yujie Luo, Yuanjian Fang, Ruiqing Kang, Cameron Lenahan, Marcin Gamdzyk, Zeyu Zhang, Takeshi Okada, Jiping Tang, Sheng Chen, John H. Zhang

Physiology Division

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	3320-3331
Number of pages	12
Journal	Stroke
Volume	51
Issue number	11
DOIs	https://doi.org/10.1161/STROKEAHA.120.029951
State	Published - Nov 2020

ASJC Scopus Subject Areas

Clinical Neurology
Cardiology and Cardiovascular Medicine
Advanced and Specialized Nursing

Keywords

enhancer of zeste homolog 2
inflammation
neuroprotection
subarachnoid hemorrhage
Subarachnoid Hemorrhage/immunology
Histones/drug effects
Male
TNF Receptor-Associated Factor 6/drug effects
Inflammation/immunology
Brain/drug effects
Clustered Regularly Interspaced Short Palindromic Repeats
Histone Code
NF-kappa B/drug effects
Disease Models, Animal
Microglia/drug effects
Morris Water Maze Test
Signal Transduction
Enhancer of Zeste Homolog 2 Protein/antagonists & inhibitors
Rats
Benzamides/pharmacology
Biphenyl Compounds
Morpholines
Rats, Sprague-Dawley
Rotarod Performance Test
Animals
Neutrophil Infiltration/drug effects
Suppressor of Cytokine Signaling 3 Protein/drug effects
Pyridones/pharmacology
RNA, Small Interfering

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Luo, Y., Fang, Y., Kang, R., Lenahan, C., Gamdzyk, M., Zhang, Z., Okada, T., Tang, J., Chen, S., & Zhang, J. H. (2020). Inhibition of EZH2 (Enhancer of Zeste Homolog 2) Attenuates Neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB (Trimethylation of Histone 3 Lysine 27/Suppressor of Cytokine Signaling 3/Tumor Necrosis Factor Receptor Family 6/Nuclear Factor-κB) in a Rat Model of Subarachnoid Hemorrhage. Stroke, 51(11), 3320-3331. https://doi.org/10.1161/STROKEAHA.120.029951

Inhibition of EZH2 (Enhancer of Zeste Homolog 2) Attenuates Neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB (Trimethylation of Histone 3 Lysine 27/Suppressor of Cytokine Signaling 3/Tumor Necrosis Factor Receptor Family 6/Nuclear Factor-κB) in a Rat Model of Subarachnoid Hemorrhage. / Luo, Yujie; Fang, Yuanjian; Kang, Ruiqing et al.
In: Stroke, Vol. 51, No. 11, 11.2020, p. 3320-3331.

Research output: Contribution to journal › Article › peer-review

Luo, Y, Fang, Y, Kang, R, Lenahan, C, Gamdzyk, M, Zhang, Z, Okada, T, Tang, J , Chen, S & Zhang, JH 2020, 'Inhibition of EZH2 (Enhancer of Zeste Homolog 2) Attenuates Neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB (Trimethylation of Histone 3 Lysine 27/Suppressor of Cytokine Signaling 3/Tumor Necrosis Factor Receptor Family 6/Nuclear Factor-κB) in a Rat Model of Subarachnoid Hemorrhage', Stroke, vol. 51, no. 11, pp. 3320-3331. https://doi.org/10.1161/STROKEAHA.120.029951

Luo Y, Fang Y, Kang R, Lenahan C, Gamdzyk M, Zhang Z et al. Inhibition of EZH2 (Enhancer of Zeste Homolog 2) Attenuates Neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB (Trimethylation of Histone 3 Lysine 27/Suppressor of Cytokine Signaling 3/Tumor Necrosis Factor Receptor Family 6/Nuclear Factor-κB) in a Rat Model of Subarachnoid Hemorrhage. Stroke. 2020 Nov;51(11):3320-3331. doi: 10.1161/STROKEAHA.120.029951

Luo, Yujie ; Fang, Yuanjian ; Kang, Ruiqing et al. / Inhibition of EZH2 (Enhancer of Zeste Homolog 2) Attenuates Neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB (Trimethylation of Histone 3 Lysine 27/Suppressor of Cytokine Signaling 3/Tumor Necrosis Factor Receptor Family 6/Nuclear Factor-κB) in a Rat Model of Subarachnoid Hemorrhage. In: Stroke. 2020 ; Vol. 51, No. 11. pp. 3320-3331.

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Inhibition of EZH2 (Enhancer of Zeste Homolog 2) Attenuates Neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB (Trimethylation of Histone 3 Lysine 27/Suppressor of Cytokine Signaling 3/Tumor Necrosis Factor Receptor Family 6/Nuclear Factor-κB) in a Rat Model of Subarachnoid Hemorrhage

ASJC Scopus Subject Areas

Keywords

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