Inhibition of EGF signaling protects the diabetic retina from insulin-induced vascular leakage

  • Masahiko Sugimoto
  • , Alecia Cutler
  • , Bailey Shen
  • , Scot E. Moss
  • , Sudha K. Iyengar
  • , Ronald Klein
  • , Judah Folkman
  • , Bela Anand-Apte

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)987-995
Number of pages9
JournalAmerican Journal of Pathology
Volume183
Issue number3
DOIs
StatePublished - Sep 2013
Externally publishedYes

ASJC Scopus Subject Areas

  • Pathology and Forensic Medicine

Keywords

  • Endothelial Cells/drug effects
  • Humans
  • Retina
  • Intercellular Signaling Peptides and Proteins/metabolism
  • ErbB Receptors/antagonists & inhibitors
  • Capillary Permeability/drug effects
  • Epidermal Growth Factor/metabolism
  • Tight Junctions/metabolism
  • Female
  • Macular Edema/metabolism
  • Blood Vessels/drug effects
  • Retinal Pigment Epithelium/drug effects
  • Mice, Inbred C57BL
  • ADAM10 Protein
  • Diabetic Retinopathy/metabolism
  • Signal Transduction/drug effects
  • Amyloid Precursor Protein Secretases/metabolism
  • Insulin/pharmacology
  • Animals
  • Betacellulin
  • Membrane Proteins/metabolism
  • Protective Agents/metabolism
  • Mice
  • Protein Kinase Inhibitors/pharmacology
  • ADAM Proteins/metabolism

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