Inhibition of acid-sensing receptor GPR4 attenuates neuronal ferroptosis via RhoA/YAP signaling in a rat model of subarachnoid hemorrhage

Qiuguang He, You Zhou, Lei Wu, Lei Huang, Ye Yuan, Jerry J. Flores, Xu Luo, Yihao Tao, Xionghui Chen, Hideki Kanamaru, Siyuan Dong, Shiyi Zhu, Qian Yu, Mingyang Han, Prativa Sherchan, Jiani Li, Jiping Tang, Zongyi Xie, John H. Zhang

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)333-345
Number of pages13
JournalFree Radical Biology and Medicine
Volume225
DOIs
StatePublished - Nov 20 2024

ASJC Scopus Subject Areas

  • Biochemistry
  • Physiology (medical)

Keywords

  • Early brain injury
  • Ferroptosis
  • GPR4 antagonist
  • Neurobehavior
  • Subarachnoid hemorrhage
  • Signal Transduction
  • Rats
  • Male
  • Ferroptosis/drug effects
  • Subarachnoid Hemorrhage/metabolism
  • Rats, Sprague-Dawley
  • YAP-Signaling Proteins/metabolism
  • Animals
  • rhoA GTP-Binding Protein/metabolism
  • Neurons/metabolism
  • Receptors, G-Protein-Coupled/metabolism
  • rho GTP-Binding Proteins
  • Disease Models, Animal

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