TY - JOUR
T1 - Inhaled nitric oxide use in preterm infants in California neonatal intensive care units
AU - Handley, S. C.
AU - Steinhorn, R. H.
AU - Hopper, A. O.
AU - Govindaswami, B.
AU - Bhatt, D. R.
AU - Van Meurs, K. P.
AU - Ariagno, R. L.
AU - Gould, J. B.
AU - Lee, H. C.
N1 - Publisher Copyright:
© 2016 Nature America, Inc.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Objective:To describe inhaled nitric oxide (iNO) exposure in preterm infants and variation in neonatal intensive care unit (NICU) use.Study Design:This was a retrospective cohort study of infants, 22 to 33+6/7 weeks of gestational age (GA), during 2005 to 2013. Analyses were stratified by GA and included population characteristics, iNO use over time and hospital variation.Results:Of the 65 824 infants, 1718 (2.61%) received iNO. Infants, 22 to 24+6/7 weeks of GA, had the highest incidence of iNO exposure (6.54%). Community NICUs (n=77, median hospital use rate 0.7%) used less iNO than regional NICUs (n=23, median hospital use rate 5.8%). In 22 to 24+6/7 weeks of GA infants, the median rate in regional centers was 10.6% (hospital interquartile range 3.8% to 22.6%).Conclusion:iNO exposure varied with GA and hospital level, with the most use in extremely premature infants and regional centers. Variation reflects a lack of consensus regarding the appropriate use of iNO for preterm infants.
AB - Objective:To describe inhaled nitric oxide (iNO) exposure in preterm infants and variation in neonatal intensive care unit (NICU) use.Study Design:This was a retrospective cohort study of infants, 22 to 33+6/7 weeks of gestational age (GA), during 2005 to 2013. Analyses were stratified by GA and included population characteristics, iNO use over time and hospital variation.Results:Of the 65 824 infants, 1718 (2.61%) received iNO. Infants, 22 to 24+6/7 weeks of GA, had the highest incidence of iNO exposure (6.54%). Community NICUs (n=77, median hospital use rate 0.7%) used less iNO than regional NICUs (n=23, median hospital use rate 5.8%). In 22 to 24+6/7 weeks of GA infants, the median rate in regional centers was 10.6% (hospital interquartile range 3.8% to 22.6%).Conclusion:iNO exposure varied with GA and hospital level, with the most use in extremely premature infants and regional centers. Variation reflects a lack of consensus regarding the appropriate use of iNO for preterm infants.
UR - https://www.scopus.com/pages/publications/84962109507
UR - https://www.scopus.com/pages/publications/84962109507#tab=citedBy
UR - https://www.mendeley.com/catalogue/ba1d91b7-4c74-39cc-bef0-1eb28297aa93/
U2 - 10.1038/jp.2016.49
DO - 10.1038/jp.2016.49
M3 - Article
C2 - 27031320
SN - 0743-8346
VL - 36
SP - 635
EP - 639
JO - Journal of perinatology : official journal of the California Perinatal Association
JF - Journal of perinatology : official journal of the California Perinatal Association
IS - 8
ER -