TY - JOUR
T1 - In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora
AU - Lin, Yuh Meei
AU - Anderson, Herbert
AU - Flavin, Michael T.
AU - Pai, Yeah Huei S.
AU - Mata-Greenwood, Eugenia
AU - Pengsuparp, Thitima
AU - Pezzuto, John M.
AU - Schinazi, Raymond F.
AU - Hughes, Stephen H.
AU - Chen, Fa Ching
N1 - Eleven biflavonoids, including amentoflavone (1), agathisflavone (2), robustaflavone (3), hinokiflavone (4), volkensiflavone (5), morelloflavone (7), rhusflavanone (9), succedaneaflavanone (10), GB-1a (11), GB-1a 7''-O-β-glucoside (13), and GB-2a (14) isolated from Rhus succedanea and Garcinia multiflora, as well as their methyl ethers, volkensiflavone hexamethyl ether (6), morelloflavone heptamethyl ether (8), and GB-1a hexamethyl ether (12), were evaluated for their anti-HIV-1 RT activity.
PY - 1997/9
Y1 - 1997/9
N2 - Eleven biflavonoids, including amentoflavone (1), agathisflavone (2), robustaflavone (3), hinokiflavone (4), volkensiflavone (5), morelloflavone (7), rhusflavanone (9), succedaneaflavanone (10), GB-1a (11), GB-1a 7'-O-β- glucoside (13), and GB-2a (141 isolated from Rhus succedanea and Garcinia multiflora, as well as their methyl ethers, volkensiflavone hexamethyl ether (6), morelloflavone heptamethyl ether (8), and GB-1a hexamethyl ether (12), were evaluated for their anti-HIV-1 RT activity. The results indicated that compounds 3 and 4 demonstrated similar activity against HIV-1 reverse transcriptase (RT), with IC50 values of 65 μM. Compounds 1, 2, 7, 11, and 14 were moderately active against HIV-1 RT, with IC50 values of 119 μM, 100 μM, 116 μM, 236 μM, and 170 μM, respectively. Morelloflavone (7) also demonstrated significant antiviral activity against HIV-1 (strain LAV-1) in phytohemagglutinin-stimulated primary human peripheral blood mononuclear cells at an EC50 value of 6.9 μM and a selectivity index value of approximately 10. The other biflavonoids were either weakly active, inactive, or not selective against HIV-1 in human lymphocytes.
AB - Eleven biflavonoids, including amentoflavone (1), agathisflavone (2), robustaflavone (3), hinokiflavone (4), volkensiflavone (5), morelloflavone (7), rhusflavanone (9), succedaneaflavanone (10), GB-1a (11), GB-1a 7'-O-β- glucoside (13), and GB-2a (141 isolated from Rhus succedanea and Garcinia multiflora, as well as their methyl ethers, volkensiflavone hexamethyl ether (6), morelloflavone heptamethyl ether (8), and GB-1a hexamethyl ether (12), were evaluated for their anti-HIV-1 RT activity. The results indicated that compounds 3 and 4 demonstrated similar activity against HIV-1 reverse transcriptase (RT), with IC50 values of 65 μM. Compounds 1, 2, 7, 11, and 14 were moderately active against HIV-1 RT, with IC50 values of 119 μM, 100 μM, 116 μM, 236 μM, and 170 μM, respectively. Morelloflavone (7) also demonstrated significant antiviral activity against HIV-1 (strain LAV-1) in phytohemagglutinin-stimulated primary human peripheral blood mononuclear cells at an EC50 value of 6.9 μM and a selectivity index value of approximately 10. The other biflavonoids were either weakly active, inactive, or not selective against HIV-1 in human lymphocytes.
UR - https://www.scopus.com/pages/publications/14444285699
UR - https://www.scopus.com/pages/publications/14444285699#tab=citedBy
U2 - 10.1021/np9700275
DO - 10.1021/np9700275
M3 - Article
C2 - 9322359
SN - 0163-3864
VL - 60
SP - 884
EP - 888
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 9
ER -