Immunological response in early brain injury after SAH

Takumi Sozen; Reiko Tsuchiyama; Yu Hasegawa; Hidenori Suzuki; Vikram Jadhav; Shigeru Nishizawa; John H. Zhang

doi:10.1007/978-3-7091-0353-1_10

Immunological response in early brain injury after SAH

Takumi Sozen
, Reiko Tsuchiyama
, Yu Hasegawa
, Hidenori Suzuki
, Vikram Jadhav
, Shigeru Nishizawa
, John H. Zhang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This study summarized the role of inflammation in the early brain injury after subarachnoid hemorrhage. Elevation of cytokines, activation of MMPs and phosphorylation of MAPK contributes to neuronal apoptosis and brain edema. Anti-inflammation may be potential strategy for the prevention and suppression of early brain injury after subarachnoid hemorrhage. © 2011 Springer-Verlag/Wien.

Original language	English
Title of host publication	Early Brain Injury or Cerebral Vasospasm
Subtitle of host publication	Volume 1: Pathophysiology
Publisher	Springer Vienna
Pages	57-61
Number of pages	5
ISBN (Electronic)	978-3-7091-0353-1
ISBN (Print)	9783709103524, 978-3-7091-1658-6
DOIs	https://doi.org/10.1007/978-3-7091-0353-1_10
State	Published - Jan 1 2011

Publication series

Name	Acta Neurochirurgica, Supplementum
Volume	110
ISSN (Print)	0065-1419
ISSN (Electronic)	0001-6268

ASJC Scopus Subject Areas

Surgery
Clinical Neurology

Keywords

Early brain injury
Immune
Inflammation
Matrix Metalloproteinase 9/metabolism
Amino Acid Chloromethyl Ketones/therapeutic use
Humans
Encephalitis/etiology
Subarachnoid Hemorrhage/complications
Brain Edema/etiology
Animals
Brain Injuries/drug therapy
Enzyme Inhibitors/therapeutic use
Mitogen-Activated Protein Kinase Kinases/metabolism
Cytokines/metabolism
Gene Expression Regulation/drug effects

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title = "Immunological response in early brain injury after SAH",

abstract = "This study summarized the role of inflammation in the early brain injury after subarachnoid hemorrhage. Elevation of cytokines, activation of MMPs and phosphorylation of MAPK contributes to neuronal apoptosis and brain edema. Anti-inflammation may be potential strategy for the prevention and suppression of early brain injury after subarachnoid hemorrhage. {\textcopyright} 2011 Springer-Verlag/Wien.",

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author = "Takumi Sozen and Reiko Tsuchiyama and Yu Hasegawa and Hidenori Suzuki and Vikram Jadhav and Shigeru Nishizawa and Zhang, \{John H.\}",

note = "Funding Information: This study was partially supported by grants (NS053407) from the National Institutes of Health to J.H.Z.",

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AU - Suzuki, Hidenori

AU - Jadhav, Vikram

AU - Nishizawa, Shigeru

AU - Zhang, John H.

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KW - Inflammation

KW - Matrix Metalloproteinase 9/metabolism

KW - Amino Acid Chloromethyl Ketones/therapeutic use

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KW - Encephalitis/etiology

KW - Subarachnoid Hemorrhage/complications

KW - Brain Edema/etiology

KW - Animals

KW - Brain Injuries/drug therapy

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KW - Mitogen-Activated Protein Kinase Kinases/metabolism

KW - Cytokines/metabolism

KW - Gene Expression Regulation/drug effects

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BT - Early Brain Injury or Cerebral Vasospasm

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ER -

Immunological response in early brain injury after SAH

Abstract

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ASJC Scopus Subject Areas

Keywords

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