Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

Anjali Ramaswamy; Nina N. Brodsky; Tomokazu S. Sumida; Michela Comi; Hiromitsu Asashima; Kenneth B. Hoehn; Ningshan Li; Yunqing Liu; Aagam Shah; Neal G. Ravindra; Jason Bishai; Alamzeb Khan; William Lau; Brian Sellers; Neha Bansal; Pamela Guerrerio; Avraham Unterman; Victoria Habet; Andrew J. Rice; Jason Catanzaro; Harsha Chandnani; Merrick Lopez; Naftali Kaminski; Charles S. Dela Cruz; John S. Tsang; Zuoheng Wang; Xiting Yan; Steven H. Kleinstein; David van Dijk; Richard W. Pierce; David A. Hafler; Carrie L. Lucas

doi:10.1016/j.immuni.2021.04.003

Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

Anjali Ramaswamy
, Nina N. Brodsky
, Tomokazu S. Sumida
, Michela Comi
, Hiromitsu Asashima
, Kenneth B. Hoehn
, Ningshan Li
, Yunqing Liu
, Aagam Shah
, Neal G. Ravindra
, Jason Bishai
, Alamzeb Khan
, William Lau
, Brian Sellers
, Neha Bansal
, Pamela Guerrerio
, Avraham Unterman
, Victoria Habet
, Andrew J. Rice
, Jason Catanzaro

Harsha Chandnani, Merrick Lopez, Naftali Kaminski, Charles S. Dela Cruz, John S. Tsang, Zuoheng Wang, Xiting Yan, Steven H. Kleinstein, David van Dijk, Richard W. Pierce, David A. Hafler, Carrie L. Lucas

Pediatrics

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1083-1095.e7
Journal	Immunity
Volume	54
Issue number	5
DOIs	https://doi.org/10.1016/j.immuni.2021.04.003
State	Published - May 11 2021

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Infectious Diseases

Keywords

MIS-C
SARS-CoV-2
TRBV11-2
alarmins
cytotoxicity
inflammation
pediatric
plasmablasts
Killer Cells, Natural/immunology
Cytotoxicity, Immunologic/genetics
Humans
Child, Preschool
COVID-19/immunology
Alarmins/immunology
Endothelium/immunology
Myeloid Cells/immunology
CD8-Positive T-Lymphocytes/immunology
Child
Severity of Illness Index
Receptors, Antigen, T-Cell/genetics
Autoantibodies/immunology
Systemic Inflammatory Response Syndrome/immunology
SARS-CoV-2/immunology
Adolescent
Plasma Cells/immunology

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Ramaswamy, A., Brodsky, N. N., Sumida, T. S., Comi, M., Asashima, H., Hoehn, K. B., Li, N., Liu, Y., Shah, A., Ravindra, N. G., Bishai, J., Khan, A., Lau, W., Sellers, B., Bansal, N., Guerrerio, P., Unterman, A., Habet, V., Rice, A. J., ... Lucas, C. L. (2021). Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children. Immunity, 54(5), 1083-1095.e7. https://doi.org/10.1016/j.immuni.2021.04.003

Ramaswamy, A, Brodsky, NN, Sumida, TS, Comi, M, Asashima, H, Hoehn, KB, Li, N, Liu, Y, Shah, A, Ravindra, NG, Bishai, J, Khan, A, Lau, W, Sellers, B, Bansal, N, Guerrerio, P, Unterman, A, Habet, V, Rice, AJ, Catanzaro, J, Chandnani, H , Lopez, M, Kaminski, N, Dela Cruz, CS, Tsang, JS, Wang, Z, Yan, X, Kleinstein, SH, van Dijk, D, Pierce, RW, Hafler, DA & Lucas, CL 2021, 'Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children', Immunity, vol. 54, no. 5, pp. 1083-1095.e7. https://doi.org/10.1016/j.immuni.2021.04.003

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AU - Brodsky, Nina N.

AU - Sumida, Tomokazu S.

AU - Comi, Michela

AU - Asashima, Hiromitsu

AU - Hoehn, Kenneth B.

AU - Li, Ningshan

AU - Liu, Yunqing

AU - Shah, Aagam

AU - Ravindra, Neal G.

AU - Bishai, Jason

AU - Khan, Alamzeb

AU - Lau, William

AU - Sellers, Brian

AU - Bansal, Neha

AU - Guerrerio, Pamela

AU - Unterman, Avraham

AU - Habet, Victoria

AU - Rice, Andrew J.

AU - Catanzaro, Jason

AU - Chandnani, Harsha

AU - Lopez, Merrick

AU - Kaminski, Naftali

AU - Dela Cruz, Charles S.

AU - Tsang, John S.

AU - Wang, Zuoheng

AU - Yan, Xiting

AU - Kleinstein, Steven H.

AU - van Dijk, David

AU - Pierce, Richard W.

AU - Hafler, David A.

AU - Lucas, Carrie L.

PY - 2021/5/11

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KW - SARS-CoV-2

KW - TRBV11-2

KW - alarmins

KW - cytotoxicity

KW - inflammation

KW - pediatric

KW - plasmablasts

KW - Killer Cells, Natural/immunology

KW - Cytotoxicity, Immunologic/genetics

KW - Humans

KW - Child, Preschool

KW - COVID-19/immunology

KW - Alarmins/immunology

KW - Endothelium/immunology

KW - Myeloid Cells/immunology

KW - CD8-Positive T-Lymphocytes/immunology

KW - Child

KW - Severity of Illness Index

KW - Receptors, Antigen, T-Cell/genetics

KW - Autoantibodies/immunology

KW - Systemic Inflammatory Response Syndrome/immunology

KW - SARS-CoV-2/immunology

KW - Adolescent

KW - Plasma Cells/immunology

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SN - 1074-7613

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SP - 1083-1095.e7

JO - Immunity

JF - Immunity

IS - 5

ER -

Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

ASJC Scopus Subject Areas

Keywords

Access to Document

OpenUrl availability

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