Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

Anjali Ramaswamy; Nina N. Brodsky; Tomokazu S. Sumida; Michela Comi; Hiromitsu Asashima; Kenneth B. Hoehn; Ningshan Li; Yunqing Liu; Aagam Shah; Neal G. Ravindra; Jason Bishai; Alamzeb Khan; William Lau; Brian Sellers; Neha Bansal; Pamela Guerrerio; Avraham Unterman; Victoria Habet; Andrew J. Rice; Jason Catanzaro; Harsha Chandnani; Merrick Lopez; Naftali Kaminski; Charles S. Dela Cruz; John S. Tsang; Zuoheng Wang; Xiting Yan; Steven H. Kleinstein; David van Dijk; Richard W. Pierce; David A. Hafler; Carrie L. Lucas

doi:10.1016/j.immuni.2021.04.003

Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

Anjali Ramaswamy, Nina N. Brodsky, Tomokazu S. Sumida, Michela Comi, Hiromitsu Asashima, Kenneth B. Hoehn, Ningshan Li, Yunqing Liu, Aagam Shah, Neal G. Ravindra, Jason Bishai, Alamzeb Khan, William Lau, Brian Sellers, Neha Bansal, Pamela Guerrerio, Avraham Unterman, Victoria Habet, Andrew J. Rice, Jason CatanzaroHarsha Chandnani, Merrick Lopez, Naftali Kaminski, Charles S. Dela Cruz, John S. Tsang, Zuoheng Wang, Xiting Yan, Steven H. Kleinstein, David van Dijk, Richard W. Pierce, David A. Hafler, Carrie L. Lucas

Pediatric Intensive Care Division

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1083-1095.e7
Journal	Immunity
Volume	54
Issue number	5
DOIs	https://doi.org/10.1016/j.immuni.2021.04.003
State	Published - May 11 2021

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Infectious Diseases

Keywords

MIS-C
SARS-CoV-2
TRBV11-2
alarmins
cytotoxicity
inflammation
pediatric
plasmablasts

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10.1016/j.immuni.2021.04.003

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Ramaswamy, A., Brodsky, N. N., Sumida, T. S., Comi, M., Asashima, H., Hoehn, K. B., Li, N., Liu, Y., Shah, A., Ravindra, N. G., Bishai, J., Khan, A., Lau, W., Sellers, B., Bansal, N., Guerrerio, P., Unterman, A., Habet, V., Rice, A. J., ... Lucas, C. L. (2021). Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children. Immunity, 54(5), 1083-1095.e7. https://doi.org/10.1016/j.immuni.2021.04.003

Ramaswamy, A, Brodsky, NN, Sumida, TS, Comi, M, Asashima, H, Hoehn, KB, Li, N, Liu, Y, Shah, A, Ravindra, NG, Bishai, J, Khan, A, Lau, W, Sellers, B, Bansal, N, Guerrerio, P, Unterman, A, Habet, V, Rice, AJ, Catanzaro, J, Chandnani, H , Lopez, M, Kaminski, N, Dela Cruz, CS, Tsang, JS, Wang, Z, Yan, X, Kleinstein, SH, van Dijk, D, Pierce, RW, Hafler, DA & Lucas, CL 2021, 'Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children', Immunity, vol. 54, no. 5, pp. 1083-1095.e7. https://doi.org/10.1016/j.immuni.2021.04.003

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title = "Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children",

keywords = "MIS-C, SARS-CoV-2, TRBV11-2, alarmins, cytotoxicity, inflammation, pediatric, plasmablasts",

author = "Anjali Ramaswamy and Brodsky, {Nina N.} and Sumida, {Tomokazu S.} and Michela Comi and Hiromitsu Asashima and Hoehn, {Kenneth B.} and Ningshan Li and Yunqing Liu and Aagam Shah and Ravindra, {Neal G.} and Jason Bishai and Alamzeb Khan and William Lau and Brian Sellers and Neha Bansal and Pamela Guerrerio and Avraham Unterman and Victoria Habet and Rice, {Andrew J.} and Jason Catanzaro and Harsha Chandnani and Merrick Lopez and Naftali Kaminski and {Dela Cruz}, {Charles S.} and Tsang, {John S.} and Zuoheng Wang and Xiting Yan and Kleinstein, {Steven H.} and {van Dijk}, David and Pierce, {Richard W.} and Hafler, {David A.} and Lucas, {Carrie L.}",

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year = "2021",

month = may,

day = "11",

doi = "10.1016/j.immuni.2021.04.003",

language = "English",

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T1 - Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

AU - Ramaswamy, Anjali

AU - Brodsky, Nina N.

AU - Sumida, Tomokazu S.

AU - Comi, Michela

AU - Asashima, Hiromitsu

AU - Hoehn, Kenneth B.

AU - Li, Ningshan

AU - Liu, Yunqing

AU - Shah, Aagam

AU - Ravindra, Neal G.

AU - Bishai, Jason

AU - Khan, Alamzeb

AU - Lau, William

AU - Sellers, Brian

AU - Bansal, Neha

AU - Guerrerio, Pamela

AU - Unterman, Avraham

AU - Habet, Victoria

AU - Rice, Andrew J.

AU - Catanzaro, Jason

AU - Chandnani, Harsha

AU - Lopez, Merrick

AU - Kaminski, Naftali

AU - Dela Cruz, Charles S.

AU - Tsang, John S.

AU - Wang, Zuoheng

AU - Yan, Xiting

AU - Kleinstein, Steven H.

AU - van Dijk, David

AU - Pierce, Richard W.

AU - Hafler, David A.

AU - Lucas, Carrie L.

PY - 2021/5/11

Y1 - 2021/5/11

KW - MIS-C

KW - SARS-CoV-2

KW - TRBV11-2

KW - alarmins

KW - cytotoxicity

KW - inflammation

KW - pediatric

KW - plasmablasts

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DO - 10.1016/j.immuni.2021.04.003

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SN - 1074-7613

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JO - Immunity

JF - Immunity

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ER -

Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

ASJC Scopus Subject Areas

Keywords

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