Ikaros and tumor suppression in acute Lymphoblastic leukemia

Kimberly J. Payne; Sinisa Dovat

doi:10.1615/CritRevOncog.v16.i1-2.20

Ikaros and tumor suppression in acute Lymphoblastic leukemia

Kimberly J. Payne
, Sinisa Dovat

Loma Linda University

Research output: Contribution to journal › Review article › peer-review

Abstract

The Ikzf1 gene encodes Ikaros-a DNA-binding zinc finger protein. Ikaros functions as a regulator of gene expression and chromatin remodeling. The biological roles of Ikaros include regulating the development and function of the immune system and acting as a master regulator of hematopoietic differentiation. Genomic profiling studies identified Ikzf1 as an important tumor suppressor in acute lymphoblastic leukemia (ALL), particularly in ALL that is associated with poor prognosis. This review summarizes currently available data regarding the structure and function of Ikaros, the clinical relevance of genetic inactivation of Ikzf1, and signal transduction pathways that regulate Ikaros function. © 2011 by Begell House, Inc.

Original language	English
Pages (from-to)	3-12
Number of pages	10
Journal	Critical Reviews in Oncogenesis
Volume	16
Issue number	1-2
DOIs	https://doi.org/10.1615/CritRevOncog.v16.i1-2.20
State	Published - 2011

ASJC Scopus Subject Areas

Cancer Research

Keywords

ALL
CK2
Casein kinase
Deletion
High-risk
Ikaros
Leukemia
Microarray
Phosphorylation
Tumor suppression

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title = "Ikaros and tumor suppression in acute Lymphoblastic leukemia",

abstract = "The Ikzf1 gene encodes Ikaros-a DNA-binding zinc finger protein. Ikaros functions as a regulator of gene expression and chromatin remodeling. The biological roles of Ikaros include regulating the development and function of the immune system and acting as a master regulator of hematopoietic differentiation. Genomic profiling studies identified Ikzf1 as an important tumor suppressor in acute lymphoblastic leukemia (ALL), particularly in ALL that is associated with poor prognosis. This review summarizes currently available data regarding the structure and function of Ikaros, the clinical relevance of genetic inactivation of Ikzf1, and signal transduction pathways that regulate Ikaros function. {\textcopyright} 2011 by Begell House, Inc.",

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KW - ALL

KW - CK2

KW - Casein kinase

KW - Deletion

KW - High-risk

KW - Ikaros

KW - Leukemia

KW - Microarray

KW - Phosphorylation

KW - Tumor suppression

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DO - 10.1615/CritRevOncog.v16.i1-2.20

M3 - Review article

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JO - Critical Reviews in Oncogenesis

JF - Critical Reviews in Oncogenesis

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ER -

Ikaros and tumor suppression in acute Lymphoblastic leukemia

Abstract

ASJC Scopus Subject Areas

Keywords

Access to Document

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