Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis

Jessica Deree; Joilson O. Martins; Alex Leedom; Brian Lamon; James Putnam; Tercio De Campos; David B. Hoyt; Paul Wolf; Raul Coimbra

doi:10.1097/TA.0b013e31802d96cb

Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis

Jessica Deree
, Joilson O. Martins
, Alex Leedom
, Brian Lamon
, James Putnam
, Tercio De Campos
, David B. Hoyt
, Paul Wolf
, Raul Coimbra

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	104-111
Number of pages	8
Journal	Journal of Trauma - Injury, Infection and Critical Care
Volume	62
Issue number	1
DOIs	https://doi.org/10.1097/TA.0b013e31802d96cb
State	Published - Jan 2007
Externally published	Yes

ASJC Scopus Subject Areas

Surgery
Critical Care and Intensive Care Medicine

Keywords

Acute lung injury
Hemeoxygenase-1
Hemorrhagic shock
Hypertonic saline
Inflammation
Interleukin-8
Matrix metalloproteinases
Pentoxifylline
Immunohistochemistry
Inflammation Mediators/metabolism
Heme Oxygenase-1/metabolism
Pentoxifylline/pharmacology
Shock, Hemorrhagic/therapy
Male
Saline Solution, Hypertonic/pharmacology
Neutrophil Activation/drug effects
Matrix Metalloproteinase 2/metabolism
Respiratory Distress Syndrome/etiology
Lung/metabolism
Monocyte Chemoattractant Proteins/metabolism
Matrix Metalloproteinase 9/metabolism
Cell Degranulation
Enzyme-Linked Immunosorbent Assay
Rats
Bronchoalveolar Lavage Fluid/chemistry
Random Allocation
Rats, Sprague-Dawley
Animals
Fluid Therapy/adverse effects
Neutrophils/physiology

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10.1097/TA.0b013e31802d96cb

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Deree, J., Martins, J. O., Leedom, A., Lamon, B., Putnam, J., De Campos, T., Hoyt, D. B., Wolf, P., & Coimbra, R. (2007). Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis. Journal of Trauma - Injury, Infection and Critical Care, 62(1), 104-111. https://doi.org/10.1097/TA.0b013e31802d96cb

Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis. / Deree, Jessica; Martins, Joilson O.; Leedom, Alex et al.
In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 62, No. 1, 01.2007, p. 104-111.

Research output: Contribution to journal › Article › peer-review

Deree, J, Martins, JO, Leedom, A, Lamon, B, Putnam, J, De Campos, T, Hoyt, DB, Wolf, P & Coimbra, R 2007, 'Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis', Journal of Trauma - Injury, Infection and Critical Care, vol. 62, no. 1, pp. 104-111. https://doi.org/10.1097/TA.0b013e31802d96cb

Deree J, Martins JO, Leedom A, Lamon B, Putnam J, De Campos T et al. Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis. Journal of Trauma - Injury, Infection and Critical Care. 2007 Jan;62(1):104-111. doi: 10.1097/TA.0b013e31802d96cb

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Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis

ASJC Scopus Subject Areas

Keywords

Access to Document

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