TY - JOUR
T1 - Hyperbaric oxygen therapy promotes neurogenesis
T2 - Where do we stand?
AU - Mu, Jun
AU - Krafft, Paul R.
AU - Zhang, John H.
PY - 2011/6/27
Y1 - 2011/6/27
N2 - Neurogenesis in adults, initiated by injury to the central nervous system (CNS) presents an autologous repair mechanism. It has been suggested that hyperbaric oxygen therapy (HBOT) enhances neurogenesis which accordingly may improve functional outcome after CNS injury. In this present article we aim to review experimental as well as clinical studies on the subject of HBOT and neurogenesis. We demonstrate hypothetical mechanism of HBOT on cellular transcription factors including hypoxia-inducible factors (HIFs) and cAMP response element binding (CREB). We furthermore reveal the discrepancy between experimental findings and clinical trials in regards of HBOT. Further translational preclinical studies followed by improved clinical trials are needed to elucidate potential benefits of HBOT. © 2011 Mu et al; licensee BioMed Central Ltd.
AB - Neurogenesis in adults, initiated by injury to the central nervous system (CNS) presents an autologous repair mechanism. It has been suggested that hyperbaric oxygen therapy (HBOT) enhances neurogenesis which accordingly may improve functional outcome after CNS injury. In this present article we aim to review experimental as well as clinical studies on the subject of HBOT and neurogenesis. We demonstrate hypothetical mechanism of HBOT on cellular transcription factors including hypoxia-inducible factors (HIFs) and cAMP response element binding (CREB). We furthermore reveal the discrepancy between experimental findings and clinical trials in regards of HBOT. Further translational preclinical studies followed by improved clinical trials are needed to elucidate potential benefits of HBOT. © 2011 Mu et al; licensee BioMed Central Ltd.
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UR - https://www.mendeley.com/catalogue/b1a1c811-e308-3277-acf1-f8b7448a5f88/
U2 - 10.1186/2045-9912-1-14
DO - 10.1186/2045-9912-1-14
M3 - Review article
C2 - 22146131
SN - 2045-9912
VL - 1
JO - Medical Gas Research
JF - Medical Gas Research
IS - 1
M1 - 14
ER -