TY - JOUR
T1 - Hyperbaric oxygen therapy for post concussion symptoms
T2 - Issues may affect the results
AU - Hu, Qin
AU - Manaenko, Anatol
AU - Guo, Zhenni
AU - Huang, Lei
AU - Tang, Jiping
AU - Zhang, John H.
N1 - Publisher Copyright:
© 2015 Hu et al.
PY - 2015/8/25
Y1 - 2015/8/25
N2 - Post concussion syndrome (PCS) is a set of symptoms succeeding in 25 % of mild traumatic brain injury (mTBI) patients. Hyperbaric oxygen therapy (HBOT) has been demonstrated as an effective method for treating acute and severe TBI, but its efficacy in PCS remains controversial. In this editorial, we reviewed the clinical studies of HBOT in PCS, summarized the limitations of these studies, and discussed the limitations: inappropriate Sham group using room air at 1.2 or 1.3 ATA; delayed HBO administration; subjective assessment methods; time point for outcome assessment and small sample size. We hope that our concerns will be helpful for future clinical studies of HBO therapy in TBI or other neurological disorders.
AB - Post concussion syndrome (PCS) is a set of symptoms succeeding in 25 % of mild traumatic brain injury (mTBI) patients. Hyperbaric oxygen therapy (HBOT) has been demonstrated as an effective method for treating acute and severe TBI, but its efficacy in PCS remains controversial. In this editorial, we reviewed the clinical studies of HBOT in PCS, summarized the limitations of these studies, and discussed the limitations: inappropriate Sham group using room air at 1.2 or 1.3 ATA; delayed HBO administration; subjective assessment methods; time point for outcome assessment and small sample size. We hope that our concerns will be helpful for future clinical studies of HBO therapy in TBI or other neurological disorders.
KW - Clinical studies
KW - Hyperbaric oxygen therapy
KW - Post concussion syndrome
UR - http://www.scopus.com/inward/record.url?scp=85006192448&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006192448&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/7c23fbf0-65f8-3f71-bfaa-2eff5baaefca/
U2 - 10.1186/s13618-015-0033-3
DO - 10.1186/s13618-015-0033-3
M3 - Comment/debate
SN - 2045-9912
VL - 5
JO - Medical Gas Research
JF - Medical Gas Research
IS - 1
M1 - 10
ER -