TY - JOUR
T1 - Hyperbaric oxygen preconditioning
T2 - A reliable option for neuroprotection
AU - Hu, Qin
AU - Manaenko, Anatol
AU - Matei, Nathanael
AU - Guo, Zhenni
AU - Xu, Ting
AU - Tang, Jiping
AU - Zhang, John
N1 - Med Gas Res. 2016 Apr 4;6(1):20-32. eCollection 2016 Mar. Review
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Brain injury is the leading cause of death and disability worldwide and clinically there is no effective therapy for neuroprotection. Hyperbaric oxygen preconditioning (HBO-PC) has been experimentally demonstrated to be neuroprotective in several models and has shown efficiency in patients undergoing on-pump coronary artery bypass graft (CABG) surgery. Compared with other preconditioning stimuli, HBO is benign and has clinically translational potential. In this review, we will summarize the results in experimental brain injury and clinical studies, elaborate the mechanisms of HBO-PC, and discuss regimes and opinions for future interventions in acute brain injury.
AB - Brain injury is the leading cause of death and disability worldwide and clinically there is no effective therapy for neuroprotection. Hyperbaric oxygen preconditioning (HBO-PC) has been experimentally demonstrated to be neuroprotective in several models and has shown efficiency in patients undergoing on-pump coronary artery bypass graft (CABG) surgery. Compared with other preconditioning stimuli, HBO is benign and has clinically translational potential. In this review, we will summarize the results in experimental brain injury and clinical studies, elaborate the mechanisms of HBO-PC, and discuss regimes and opinions for future interventions in acute brain injury.
KW - hyperbaric oxygen preconditioning
KW - ischemic stroke
KW - neonatal hypoxic-ischemia
KW - neuroprotection
KW - traumatic brain injury
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UR - https://www.mendeley.com/catalogue/ce23b793-d1a6-3949-917c-6fe2e709be06/
U2 - 10.4103/2045-9912.179337
DO - 10.4103/2045-9912.179337
M3 - Review article
SN - 2045-9912
VL - 6
SP - 20
EP - 32
JO - Medical Gas Research
JF - Medical Gas Research
IS - 1
ER -