Hydrolysis of N3-methyl-2′-deoxycytidine: Model compound for reactivity of protonated cytosine residues in DNA

Lawrence C. Sowers; W. David Sedwick; Barbara Ramsay Shaw

doi:10.1016/0027-5107(89)90225-X

Hydrolysis of N³-methyl-2′-deoxycytidine: Model compound for reactivity of protonated cytosine residues in DNA

Lawrence C. Sowers, W. David Sedwick, Barbara Ramsay Shaw

Basic Sciences

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	131-138
Number of pages	8
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	215
Issue number	1
DOIs	https://doi.org/10.1016/0027-5107(89)90225-X
State	Published - Nov 1989

ASJC Scopus Subject Areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

Keywords

Cytosine residues, protonation
DNA
Deamination reaction rates
Depyrimidination reaction rates
N-Methyl-2′-deoxycytidine
Protonated cytosine residues
protonated cytosine residues

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10.1016/0027-5107(89)90225-X

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Cite this

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title = "Hydrolysis of N3-methyl-2′-deoxycytidine: Model compound for reactivity of protonated cytosine residues in DNA",

keywords = "Cytosine residues, protonation, DNA, Deamination reaction rates, Depyrimidination reaction rates, N-Methyl-2′-deoxycytidine, Protonated cytosine residues, protonated cytosine residues",

author = "Sowers, {Lawrence C.} and {David Sedwick}, W. and Shaw, {Barbara Ramsay}",

note = "Funding Information: This work was supported in part by the following sources. NCI core grants CA33572 (LCS) and P30CA43703 (WDS), NIH grant GM 41336 (LCS), NCI research grant CA31110 (WDS), a grant from Galaxo, Inc. (WDS), NIH grant CA 44709 (BRS), American Cancer Society grants BC 573 and BC 617 (BRS) and American Cancer Society faculty research award FRA 310 (BRS).",

year = "1989",

month = nov,

doi = "10.1016/0027-5107(89)90225-X",

language = "English",

volume = "215",

pages = "131--138",

journal = "Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis",

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T1 - Hydrolysis of N3-methyl-2′-deoxycytidine

T2 - Model compound for reactivity of protonated cytosine residues in DNA

AU - Sowers, Lawrence C.

AU - David Sedwick, W.

AU - Shaw, Barbara Ramsay

N1 - Funding Information: This work was supported in part by the following sources. NCI core grants CA33572 (LCS) and P30CA43703 (WDS), NIH grant GM 41336 (LCS), NCI research grant CA31110 (WDS), a grant from Galaxo, Inc. (WDS), NIH grant CA 44709 (BRS), American Cancer Society grants BC 573 and BC 617 (BRS) and American Cancer Society faculty research award FRA 310 (BRS).

PY - 1989/11

Y1 - 1989/11

KW - Cytosine residues, protonation

KW - DNA

KW - Deamination reaction rates

KW - Depyrimidination reaction rates

KW - N-Methyl-2′-deoxycytidine

KW - Protonated cytosine residues

KW - protonated cytosine residues

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