Hydrogen is neuroprotective against surgically induced brain injury

Jan M. Eckermann, Wanqiu Chen, Vikram Jadhav, Frank P.K. Hsu, Austin R.T. Colohan, Jiping Tang, John H. Zhang

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Neurosurgical operations cause unavoidable damage to healthy brain tissues. Direct surgical injury as well as surgically induced oxidative stress contributes to the subsequent formation of brain edema. Therefore, we tested the neuroprotective effects of hydrogen (H2) in an established surgical brain injury (SBI) model in rats. Materials and methods. Adult male Sprague - Dawley rats (weight 300-350g) were divided into three groups to serve as sham operated, SBI without treatment, and SBI treated with H 2(2.9%). Brain water content, myeloperoxidase (MPO) assay, lipid peroxidation (LPO), and neurological function were measured at 24 hrs after SBI. Results: SBI resulted in localized brain edema (p = < 0.001). Hydrogen (2.9%) administered concurrently with surgery significantly decreased the formation of cerebral edema (p = 0.028) and improved neurobehavioral score (p = 0.022). However, hydrogen treatment failed to reduce oxidative stress (LPO assay) or inflammation (MPO assay) in brain tissues. Conclusions: Hydrogen appears to be promising as an effective, yet inexpensive way to reduce cerebral edema caused by surgical procedures. Hydrogen has the potential to improve clinical outcome, decrease hospital stay, and reduce overall cost to patients and the health care system. © 2011 Eckermann et al; licensee BioMed Central Ltd.
    Original languageEnglish
    Article number7
    Pages (from-to)7
    JournalMedical Gas Research
    Volume1
    Issue number1
    DOIs
    StatePublished - May 18 2011

    ASJC Scopus Subject Areas

    • Neuroscience (miscellaneous)
    • Anesthesiology and Pain Medicine

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