Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer

Sophia A. Shahin; Ruining Wang; Shirleen I. Simargi; Altagracia Contreras; Liliana Parra Echavarria; Louise Qu; Wei Wen; Thanh Dellinger; Juli Unternaehrer; Fuyuhiko Tamanoi; Jeffrey I. Zink; Carlotta A. Glackin

doi:10.1016/j.nano.2018.04.008

Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer

Sophia A. Shahin, Ruining Wang, Shirleen I. Simargi, Altagracia Contreras, Liliana Parra Echavarria, Louise Qu, Wei Wen, Thanh Dellinger, Juli Unternaehrer, Fuyuhiko Tamanoi, Jeffrey I. Zink, Carlotta A. Glackin

Biochemistry Division

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1381-1394
Number of pages	14
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.nano.2018.04.008
State	Published - Jun 2018

ASJC Scopus Subject Areas

Bioengineering
Medicine (miscellaneous)
Molecular Medicine
Biomedical Engineering
General Materials Science
Pharmaceutical Science

Keywords

Hyaluronic acid
Mesoporous silica nanoparticle
Ovarian cancer
TWIST
siRNA
RNA, Small Interfering/administration & dosage
Tumor Burden/drug effects
Hyaluronic Acid/chemistry
Cisplatin/therapeutic use
Humans
Blotting, Western
Microscopy, Confocal
Ovarian Neoplasms/drug therapy
Animals
Twist Transcription Factors/genetics
Nanoparticles/chemistry
Cell Line, Tumor
Female
Mice
Microscopy, Fluorescence

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10.1016/j.nano.2018.04.008

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Shahin, S. A., Wang, R., Simargi, S. I., Contreras, A., Parra Echavarria, L., Qu, L., Wen, W., Dellinger, T., Unternaehrer, J., Tamanoi, F., Zink, J. I., & Glackin, C. A. (2018). Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 14(4), 1381-1394. https://doi.org/10.1016/j.nano.2018.04.008

Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer. / Shahin, Sophia A.; Wang, Ruining; Simargi, Shirleen I. et al.
In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 14, No. 4, 06.2018, p. 1381-1394.

Research output: Contribution to journal › Article › peer-review

Shahin, SA, Wang, R, Simargi, SI, Contreras, A, Parra Echavarria, L, Qu, L, Wen, W, Dellinger, T, Unternaehrer, J, Tamanoi, F, Zink, JI & Glackin, CA 2018, 'Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 14, no. 4, pp. 1381-1394. https://doi.org/10.1016/j.nano.2018.04.008

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keywords = "Hyaluronic acid, Mesoporous silica nanoparticle, Ovarian cancer, TWIST, siRNA, RNA, Small Interfering/administration & dosage, Tumor Burden/drug effects, Hyaluronic Acid/chemistry, Cisplatin/therapeutic use, Humans, Blotting, Western, Microscopy, Confocal, Ovarian Neoplasms/drug therapy, Animals, Twist Transcription Factors/genetics, Nanoparticles/chemistry, Cell Line, Tumor, Female, Mice, Microscopy, Fluorescence",

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AU - Contreras, Altagracia

AU - Parra Echavarria, Liliana

AU - Qu, Louise

AU - Wen, Wei

AU - Dellinger, Thanh

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AU - Zink, Jeffrey I.

AU - Glackin, Carlotta A.

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KW - Hyaluronic Acid/chemistry

KW - Cisplatin/therapeutic use

KW - Humans

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Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer

ASJC Scopus Subject Areas

Keywords

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