High glucose increases the expression of Gq/11α and PLC-β proteins and associated signaling in vascular smooth muscle cells

Magda Descorbeth; Madhu B. Anand-Srivastava

doi:10.1152/ajpheart.00704.2008

High glucose increases the expression of G_q/11α and PLC-β proteins and associated signaling in vascular smooth muscle cells

Magda Descorbeth
, Madhu B. Anand-Srivastava

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	H2135-H2142
Journal	American Journal of Physiology - Heart and Circulatory Physiology
Volume	295
Issue number	5
DOIs	https://doi.org/10.1152/ajpheart.00704.2008
State	Published - Nov 2008
Externally published	Yes

ASJC Scopus Subject Areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

Keywords

Gα protein
Phosphatidylinositol turnover
Phospholipase C-β
Cell Line
Receptor, Angiotensin, Type 1/metabolism
Rats
Male
Phospholipase C beta/metabolism
Endothelin-1/metabolism
Myocytes, Smooth Muscle/drug effects
Muscle, Smooth, Vascular/drug effects
Rats, Sprague-Dawley
Receptor, Endothelin A/metabolism
Signal Transduction/drug effects
GTP-Binding Protein alpha Subunits, Gq-G11/metabolism
Animals
Time Factors
Angiotensin II/metabolism
Inositol 1,4,5-Trisphosphate/metabolism
Diabetes Mellitus, Experimental/enzymology
Glucose/metabolism
Receptor, Endothelin B/metabolism

Access to Document

10.1152/ajpheart.00704.2008

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Cite this

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title = "High glucose increases the expression of Gq/11α and PLC-β proteins and associated signaling in vascular smooth muscle cells",

keywords = "Gα protein, Phosphatidylinositol turnover, Phospholipase C-β, Cell Line, Receptor, Angiotensin, Type 1/metabolism, Rats, Male, Phospholipase C beta/metabolism, Endothelin-1/metabolism, Myocytes, Smooth Muscle/drug effects, Muscle, Smooth, Vascular/drug effects, Rats, Sprague-Dawley, Receptor, Endothelin A/metabolism, Signal Transduction/drug effects, GTP-Binding Protein alpha Subunits, Gq-G11/metabolism, Animals, Time Factors, Angiotensin II/metabolism, Inositol 1,4,5-Trisphosphate/metabolism, Diabetes Mellitus, Experimental/enzymology, Glucose/metabolism, Receptor, Endothelin B/metabolism",

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year = "2008",

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language = "English",

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AU - Anand-Srivastava, Madhu B.

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KW - Phospholipase C beta/metabolism

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KW - Receptor, Endothelin A/metabolism

KW - Signal Transduction/drug effects

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KW - Time Factors

KW - Angiotensin II/metabolism

KW - Inositol 1,4,5-Trisphosphate/metabolism

KW - Diabetes Mellitus, Experimental/enzymology

KW - Glucose/metabolism

KW - Receptor, Endothelin B/metabolism

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