GW0742 reduces mast cells degranulation and attenuates neurological impairments via PPARβ/δ/CD300a/SHP1 pathway after GMH in neonatal rats

Weitian Lu, Juan Huang, Jerry Flores, Peng Li, Wenna Wang, Shengpeng Liu, John H. Zhang, Jiping Tang

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number114615
JournalExperimental Neurology
Volume372
DOIs
StatePublished - Feb 2024

ASJC Scopus Subject Areas

  • Neurology
  • Developmental Neuroscience

Keywords

  • CD300a
  • Germinal matrix hemorrhage
  • Inflammation
  • Mast cell
  • PPAR
  • PPARβ/δ
  • Animals, Newborn
  • Thiazoles/pharmacology
  • Transforming Growth Factor beta1
  • Cerebral Hemorrhage
  • Tryptases
  • Chymases
  • Humans
  • Rats
  • Rats, Sprague-Dawley
  • PPAR delta/genetics
  • Animals
  • Mast Cells/metabolism
  • RNA, Small Interfering
  • Interleukin-17
  • PPAR-beta/genetics

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