Growth hormone stimulates cortical bone formation in immature hypophysectomized rats

P. M. Schiltz; T. Ohta; D. Glass; S. Mohan; D. J. Baylink

doi:10.1080/07435809209035925

Growth hormone stimulates cortical bone formation in immature hypophysectomized rats

P. M. Schiltz, T. Ohta, D. Glass, S. Mohan, D. J. Baylink

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Abstract

Daily subcutaneous injections of rat derived growth hormone to immature, hypophysectomized rats stimulated significant increases in body weight gain, serum osteocalcin, skeletal alkaline phosphatase and incorporation of radioactive thymidine and proline into the compact bone of femurs and tibiae. Equimolar doses of insulin-like growth factor-ll did not produce similar biological effects. The data support the contention that growth hormone at equimolar concentration is a stronger osteogenic agent than is insulin-like growth factor-ll in vivo.

Original language	English
Pages (from-to)	19-30
Number of pages	12
Journal	Endocrine Research
Volume	18
Issue number	1
DOIs	https://doi.org/10.1080/07435809209035925
State	Published - Jan 1992

ASJC Scopus Subject Areas

Endocrinology

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abstract = "Daily subcutaneous injections of rat derived growth hormone to immature, hypophysectomized rats stimulated significant increases in body weight gain, serum osteocalcin, skeletal alkaline phosphatase and incorporation of radioactive thymidine and proline into the compact bone of femurs and tibiae. Equimolar doses of insulin-like growth factor-ll did not produce similar biological effects. The data support the contention that growth hormone at equimolar concentration is a stronger osteogenic agent than is insulin-like growth factor-ll in vivo.",

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AU - Baylink, D. J.

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N2 - Daily subcutaneous injections of rat derived growth hormone to immature, hypophysectomized rats stimulated significant increases in body weight gain, serum osteocalcin, skeletal alkaline phosphatase and incorporation of radioactive thymidine and proline into the compact bone of femurs and tibiae. Equimolar doses of insulin-like growth factor-ll did not produce similar biological effects. The data support the contention that growth hormone at equimolar concentration is a stronger osteogenic agent than is insulin-like growth factor-ll in vivo.

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Growth hormone stimulates cortical bone formation in immature hypophysectomized rats

Abstract

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