Glucose alters rat liver S9-mediated mutagenesis, metabolism and DNA-binding of aflatoxin B1

R. W. Teel; A. Strother

doi:10.1016/0304-3835(90)90039-Z

Glucose alters rat liver S9-mediated mutagenesis, metabolism and DNA-binding of aflatoxin B₁

Physiology and Pharmacology

Research output: Contribution to journal › Article › peer-review

Abstract

The administration of 30% glucose in drinking water to rats for 48 h caused a significant increase in the hepatic S9-mediated mutagenicity of aflatoxin B₁, in Salmonella typhimurium TA100 and in the binding of aflatoxin B₁, to calf thymus DNA in vitro. These effects correlated with a reduction in the metabolism and detoxification of aflatoxin B₁, by S9 from glucose-treated rats and suggest that the oral intake of sugar may affect the hepatocarcinogenicity of aflatoxin B₁.

Original language	English
Pages (from-to)	163-169
Number of pages	7
Journal	Cancer Letters
Volume	54
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(90)90039-Z
State	Published - Nov 5 1990

ASJC Scopus Subject Areas

Oncology
Cancer Research

Keywords

aflatoxin
glucose
metabolism
mutagenesis

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Cite this

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title = "Glucose alters rat liver S9-mediated mutagenesis, metabolism and DNA-binding of aflatoxin B1",

abstract = "The administration of 30\% glucose in drinking water to rats for 48 h caused a significant increase in the hepatic S9-mediated mutagenicity of aflatoxin B1, in Salmonella typhimurium TA100 and in the binding of aflatoxin B1, to calf thymus DNA in vitro. These effects correlated with a reduction in the metabolism and detoxification of aflatoxin B1, by S9 from glucose-treated rats and suggest that the oral intake of sugar may affect the hepatocarcinogenicity of aflatoxin B1.",

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