Gestational chronic intermittent hypoxia triggers maternal inflammation and disrupts placental stress responses

Jennifer J. Gardner; Reneé de Nazaré Oliveira da Silva; Jessica L. Bradshaw; Steve Mabry; E. Nicole Wilson; Nataliia Hula; Selina M. Tucker; Isabelle K. Gorham; Desirae Escalera; Leslie Lopez; Nicole R. Phillips; Rebecca L. Cunningham; Styliani Goulopoulou

doi:10.1152/ajpcell.00446.2025

Gestational chronic intermittent hypoxia triggers maternal inflammation and disrupts placental stress responses

Jennifer J. Gardner
, Reneé de Nazaré Oliveira da Silva
, Jessica L. Bradshaw
, Steve Mabry
, E. Nicole Wilson
, Nataliia Hula
, Selina M. Tucker
, Isabelle K. Gorham
, Desirae Escalera
, Leslie Lopez
, Nicole R. Phillips
, Rebecca L. Cunningham
, Styliani Goulopoulou

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	C630-C645
Journal	American Journal of Physiology - Cell Physiology
Volume	329
Issue number	2
DOIs	https://doi.org/10.1152/ajpcell.00446.2025
State	Published - Aug 2025

ASJC Scopus Subject Areas

Physiology
Cell Biology

Keywords

autophagy
extracellular vesicles
gestational hypoxia
placental stress response
Oxidative Stress/physiology
Hypoxia/metabolism
DNA, Mitochondrial/genetics
Placenta/metabolism
Rats
Inflammation/metabolism
Rats, Sprague-Dawley
Autophagy
Pregnancy
Animals
Female
Cytokines/metabolism

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Gardner, J. J., Oliveira da Silva, R. D. N., Bradshaw, J. L., Mabry, S., Wilson, E. N., Hula, N., Tucker, S. M., Gorham, I. K., Escalera, D., Lopez, L., Phillips, N. R., Cunningham, R. L., & Goulopoulou, S. (2025). Gestational chronic intermittent hypoxia triggers maternal inflammation and disrupts placental stress responses. American Journal of Physiology - Cell Physiology, 329(2), C630-C645. https://doi.org/10.1152/ajpcell.00446.2025

Gardner, JJ, Oliveira da Silva, RDN, Bradshaw, JL, Mabry, S, Wilson, EN, Hula, N, Tucker, SM, Gorham, IK, Escalera, D, Lopez, L, Phillips, NR, Cunningham, RL & Goulopoulou, S 2025, 'Gestational chronic intermittent hypoxia triggers maternal inflammation and disrupts placental stress responses', American Journal of Physiology - Cell Physiology, vol. 329, no. 2, pp. C630-C645. https://doi.org/10.1152/ajpcell.00446.2025

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title = "Gestational chronic intermittent hypoxia triggers maternal inflammation and disrupts placental stress responses",

keywords = "autophagy, extracellular vesicles, gestational hypoxia, placental stress response, Oxidative Stress/physiology, Hypoxia/metabolism, DNA, Mitochondrial/genetics, Placenta/metabolism, Rats, Inflammation/metabolism, Rats, Sprague-Dawley, Autophagy, Pregnancy, Animals, Female, Cytokines/metabolism",

author = "Gardner, \{Jennifer J.\} and \{Oliveira da Silva\}, \{Rene{\'e} de Nazar{\'e}\} and Bradshaw, \{Jessica L.\} and Steve Mabry and Wilson, \{E. Nicole\} and Nataliia Hula and Tucker, \{Selina M.\} and Gorham, \{Isabelle K.\} and Desirae Escalera and Leslie Lopez and Phillips, \{Nicole R.\} and Cunningham, \{Rebecca L.\} and Styliani Goulopoulou",

note = "Publisher Copyright: Copyright {\textcopyright} 2025 The Authors.",

year = "2025",

month = aug,

doi = "10.1152/ajpcell.00446.2025",

language = "English",

volume = "329",

pages = "C630--C645",

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T1 - Gestational chronic intermittent hypoxia triggers maternal inflammation and disrupts placental stress responses

AU - Gardner, Jennifer J.

AU - Oliveira da Silva, Reneé de Nazaré

AU - Bradshaw, Jessica L.

AU - Mabry, Steve

AU - Wilson, E. Nicole

AU - Hula, Nataliia

AU - Tucker, Selina M.

AU - Gorham, Isabelle K.

AU - Escalera, Desirae

AU - Lopez, Leslie

AU - Phillips, Nicole R.

AU - Cunningham, Rebecca L.

AU - Goulopoulou, Styliani

PY - 2025/8

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KW - extracellular vesicles

KW - gestational hypoxia

KW - placental stress response

KW - Oxidative Stress/physiology

KW - Hypoxia/metabolism

KW - DNA, Mitochondrial/genetics

KW - Placenta/metabolism

KW - Rats

KW - Inflammation/metabolism

KW - Rats, Sprague-Dawley

KW - Autophagy

KW - Pregnancy

KW - Animals

KW - Female

KW - Cytokines/metabolism

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IS - 2

ER -

Gestational chronic intermittent hypoxia triggers maternal inflammation and disrupts placental stress responses

ASJC Scopus Subject Areas

Keywords

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