Genomic Benchmarking Reveals Reduced and Context-Dependent Transferability of AI-Engineered Bxb1 Recombinases for Large-Fragment Genome Writing

Yi Dan Sun; Li Jun Song; Bin Liu; Chong Yan Cheng; Li Ming Zhang; Jian Ping Zhang; Xiao Bing Zhang

doi:10.1177/25731599261470587

Genomic Benchmarking Reveals Reduced and Context-Dependent Transferability of AI-Engineered Bxb1 Recombinases for Large-Fragment Genome Writing

Yi Dan Sun
, Li Jun Song
, Bin Liu
, Chong Yan Cheng
, Li Ming Zhang
, Jian Ping Zhang
, Xiao Bing Zhang

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	CRISPR Journal
DOIs	https://doi.org/10.1177/25731599261470587
State	Accepted/In press - 2026
Externally published	Yes

ASJC Scopus Subject Areas

Biotechnology
Genetics

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10.1177/25731599261470587

Cite this

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title = "Genomic Benchmarking Reveals Reduced and Context-Dependent Transferability of AI-Engineered Bxb1 Recombinases for Large-Fragment Genome Writing",

author = "Sun, \{Yi Dan\} and Song, \{Li Jun\} and Bin Liu and Cheng, \{Chong Yan\} and Zhang, \{Li Ming\} and Zhang, \{Jian Ping\} and Zhang, \{Xiao Bing\}",

note = "Publisher Copyright: {\textcopyright} The Author(s)",

year = "2026",

doi = "10.1177/25731599261470587",

language = "English",

journal = "CRISPR Journal",

issn = "2573-1599",

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TY - JOUR

T1 - Genomic Benchmarking Reveals Reduced and Context-Dependent Transferability of AI-Engineered Bxb1 Recombinases for Large-Fragment Genome Writing

AU - Sun, Yi Dan

AU - Song, Li Jun

AU - Liu, Bin

AU - Cheng, Chong Yan

AU - Zhang, Li Ming

AU - Zhang, Jian Ping

AU - Zhang, Xiao Bing

PY - 2026

Y1 - 2026

UR - https://www.scopus.com/pages/publications/105047439238

UR - https://www.scopus.com/pages/publications/105047439238#tab=citedBy

U2 - 10.1177/25731599261470587

DO - 10.1177/25731599261470587

M3 - Article

C2 - 42557963

AN - SCOPUS:105047439238

SN - 2573-1599

JO - CRISPR Journal

JF - CRISPR Journal

ER -

Genomic Benchmarking Reveals Reduced and Context-Dependent Transferability of AI-Engineered Bxb1 Recombinases for Large-Fragment Genome Writing

ASJC Scopus Subject Areas

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