Generation of mesenchymal stem cells by blood cell reprogramming

Wanqiu Chen; David J. Baylink; K. H.William Lau; Xiao Bing Zhang

doi:10.2174/1574888X10666150531173448

Generation of mesenchymal stem cells by blood cell reprogramming

Wanqiu Chen, David J. Baylink, K. H.William Lau, Xiao Bing Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

Mesenchymal stem cells (MSCs) have been successfully used to treat multiple diseases in animal studies and clinical trials. Currently, the commonly used MSCs are derived from bone marrow and adipose tissue. Alternative approaches include differentiation of induced pluripotent stem cells (iPSCs) into MSCs, or direct reprogramming of blood cells into MSCs. This review summarizes recent progresses concerning how to generate MSCs by blood cell reprogramming and how studies in cellular reprogramming may help identify new factors to expand or even rejuvenate adult MSCs. © 2016 Bentham Science Publishers.

Original language	English
Pages (from-to)	114-121
Number of pages	8
Journal	Current Stem Cell Research and Therapy
Volume	11
Issue number	2
DOIs	https://doi.org/10.2174/1574888X10666150531173448
State	Published - Jan 1 2016

ASJC Scopus Subject Areas

Medicine (miscellaneous)

Keywords

Blood
Hematopoietic cells
Induced pluripotent stem cells
Mesenchymal stem cells
Reprogramming
Blood Cells/cytology
Humans
Mesenchymal Stem Cells/cytology
Cellular Reprogramming/genetics
Adipose Tissue/cytology
Cell Differentiation/genetics
Cell Proliferation/genetics
Induced Pluripotent Stem Cells
Mesenchymal Stem Cell Transplantation

Access to Document

10.2174/1574888X10666150531173448License: Unspecified

OpenUrl availability

Full text

Cite this

@article{91e0129a0a464e6f90324c609e22a62b,

title = "Generation of mesenchymal stem cells by blood cell reprogramming",

abstract = "Mesenchymal stem cells (MSCs) have been successfully used to treat multiple diseases in animal studies and clinical trials. Currently, the commonly used MSCs are derived from bone marrow and adipose tissue. Alternative approaches include differentiation of induced pluripotent stem cells (iPSCs) into MSCs, or direct reprogramming of blood cells into MSCs. This review summarizes recent progresses concerning how to generate MSCs by blood cell reprogramming and how studies in cellular reprogramming may help identify new factors to expand or even rejuvenate adult MSCs. {\textcopyright} 2016 Bentham Science Publishers.",

keywords = "Blood, Hematopoietic cells, Induced pluripotent stem cells, Mesenchymal stem cells, Reprogramming, Blood Cells/cytology, Humans, Mesenchymal Stem Cells/cytology, Cellular Reprogramming/genetics, Adipose Tissue/cytology, Cell Differentiation/genetics, Cell Proliferation/genetics, Induced Pluripotent Stem Cells, Mesenchymal Stem Cell Transplantation",

author = "Wanqiu Chen and Baylink, {David J.} and Lau, {K. H.William} and Zhang, {Xiao Bing}",

note = "Publisher Copyright: {\textcopyright} 2016 Bentham Science Publishers.",

year = "2016",

month = jan,

day = "1",

doi = "10.2174/1574888X10666150531173448",

language = "English",

volume = "11",

pages = "114--121",

journal = "Current Stem Cell Research and Therapy",

issn = "1574-888X",

number = "2",

}

TY - JOUR

T1 - Generation of mesenchymal stem cells by blood cell reprogramming

AU - Chen, Wanqiu

AU - Baylink, David J.

AU - Lau, K. H.William

AU - Zhang, Xiao Bing

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Mesenchymal stem cells (MSCs) have been successfully used to treat multiple diseases in animal studies and clinical trials. Currently, the commonly used MSCs are derived from bone marrow and adipose tissue. Alternative approaches include differentiation of induced pluripotent stem cells (iPSCs) into MSCs, or direct reprogramming of blood cells into MSCs. This review summarizes recent progresses concerning how to generate MSCs by blood cell reprogramming and how studies in cellular reprogramming may help identify new factors to expand or even rejuvenate adult MSCs. © 2016 Bentham Science Publishers.

AB - Mesenchymal stem cells (MSCs) have been successfully used to treat multiple diseases in animal studies and clinical trials. Currently, the commonly used MSCs are derived from bone marrow and adipose tissue. Alternative approaches include differentiation of induced pluripotent stem cells (iPSCs) into MSCs, or direct reprogramming of blood cells into MSCs. This review summarizes recent progresses concerning how to generate MSCs by blood cell reprogramming and how studies in cellular reprogramming may help identify new factors to expand or even rejuvenate adult MSCs. © 2016 Bentham Science Publishers.

KW - Blood

KW - Hematopoietic cells

KW - Induced pluripotent stem cells

KW - Mesenchymal stem cells

KW - Reprogramming

KW - Blood Cells/cytology

KW - Humans

KW - Mesenchymal Stem Cells/cytology

KW - Cellular Reprogramming/genetics

KW - Adipose Tissue/cytology

KW - Cell Differentiation/genetics

KW - Cell Proliferation/genetics

KW - Induced Pluripotent Stem Cells

KW - Mesenchymal Stem Cell Transplantation

UR - http://www.scopus.com/inward/record.url?scp=84959344272&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959344272&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/2ef7b0dd-477c-324a-8267-b05a25d98750/

U2 - 10.2174/1574888X10666150531173448

DO - 10.2174/1574888X10666150531173448

M3 - Article

C2 - 26027679

SN - 1574-888X

VL - 11

SP - 114

EP - 121

JO - Current Stem Cell Research and Therapy

JF - Current Stem Cell Research and Therapy

IS - 2

ER -

Generation of mesenchymal stem cells by blood cell reprogramming

Abstract

ASJC Scopus Subject Areas

Keywords

Access to Document

OpenUrl availability

Other files and links

Cite this