Gene expression elucidates functional impact of polygenic risk for schizophrenia

Menachem Fromer; Panos Roussos; Solveig K. Sieberts; Jessica S. Johnson; David H. Kavanagh; Thanneer M. Perumal; Douglas M. Ruderfer; Edwin C. Oh; Aaron Topol; Hardik R. Shah; Lambertus L. Klei; Robin Kramer; Dalila Pinto; Zeynep H. Gümüş; A. Ercument Cicek; Kristen K. Dang; Andrew Browne; Cong Lu; Lu Xie; Ben Readhead; Eli A. Stahl; Jianqiu Xiao; Mahsa Parvizi; Tymor Hamamsy; John F. Fullard; Ying Chih Wang; Milind C. Mahajan; Jonathan M.J. Derry; Joel T. Dudley; Scott E. Hemby; Benjamin A. Logsdon; Konrad Talbot; Towfique Raj; David A. Bennett; Philip L. De Jager; Jun Zhu; Bin Zhang; Patrick F. Sullivan; Andrew Chess; Shaun M. Purcell; Leslie A. Shinobu; Lara M. Mangravite; Hiroyoshi Toyoshiba; Raquel E. Gur; Chang Gyu Hahn; David A. Lewis; Vahram Haroutunian; Mette A. Peters; Barbara K. Lipska; Joseph D. Buxbaum; Eric E. Schadt; Keisuke Hirai; Kathryn Roeder; Kristen J. Brennand; Nicholas Katsanis; Enrico Domenici; Bernie Devlin; Pamela Sklar

doi:10.1038/nn.4399

Gene expression elucidates functional impact of polygenic risk for schizophrenia

Menachem Fromer
, Panos Roussos
, Solveig K. Sieberts
, Jessica S. Johnson
, David H. Kavanagh
, Thanneer M. Perumal
, Douglas M. Ruderfer
, Edwin C. Oh
, Aaron Topol
, Hardik R. Shah
, Lambertus L. Klei
, Robin Kramer
, Dalila Pinto
, Zeynep H. Gümüş
, A. Ercument Cicek
, Kristen K. Dang
, Andrew Browne
, Cong Lu
, Lu Xie
, Ben Readhead

Eli A. Stahl, Jianqiu Xiao, Mahsa Parvizi, Tymor Hamamsy, John F. Fullard, Ying Chih Wang, Milind C. Mahajan, Jonathan M.J. Derry, Joel T. Dudley, Scott E. Hemby, Benjamin A. Logsdon, Konrad Talbot, Towfique Raj, David A. Bennett, Philip L. De Jager, Jun Zhu, Bin Zhang, Patrick F. Sullivan, Andrew Chess, Shaun M. Purcell, Leslie A. Shinobu, Lara M. Mangravite, Hiroyoshi Toyoshiba, Raquel E. Gur, Chang Gyu Hahn, David A. Lewis, Vahram Haroutunian, Mette A. Peters, Barbara K. Lipska, Joseph D. Buxbaum, Eric E. Schadt, Keisuke Hirai, Kathryn Roeder, Kristen J. Brennand, Nicholas Katsanis, Enrico Domenici, Bernie Devlin, Pamela Sklar

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1442-1453
Number of pages	12
Journal	Nature Neuroscience
Volume	19
Issue number	11
DOIs	https://doi.org/10.1038/nn.4399
State	Published - Nov 2016
Externally published	Yes

ASJC Scopus Subject Areas

General Neuroscience

Keywords

Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Female
Male
Risk
Polymorphism, Single Nucleotide
Multifactorial Inheritance/genetics
Schizophrenia/genetics
Gene Expression Regulation/genetics
Brain/metabolism

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Fromer, M., Roussos, P., Sieberts, S. K., Johnson, J. S., Kavanagh, D. H., Perumal, T. M., Ruderfer, D. M., Oh, E. C., Topol, A., Shah, H. R., Klei, L. L., Kramer, R., Pinto, D., Gümüş, Z. H., Cicek, A. E., Dang, K. K., Browne, A., Lu, C., Xie, L., ... Sklar, P. (2016). Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nature Neuroscience, 19(11), 1442-1453. https://doi.org/10.1038/nn.4399

Fromer, M, Roussos, P, Sieberts, SK, Johnson, JS, Kavanagh, DH, Perumal, TM, Ruderfer, DM, Oh, EC, Topol, A, Shah, HR, Klei, LL, Kramer, R, Pinto, D, Gümüş, ZH, Cicek, AE, Dang, KK, Browne, A, Lu, C, Xie, L, Readhead, B, Stahl, EA, Xiao, J, Parvizi, M, Hamamsy, T, Fullard, JF, Wang, YC, Mahajan, MC, Derry, JMJ, Dudley, JT, Hemby, SE, Logsdon, BA, Talbot, K, Raj, T, Bennett, DA, De Jager, PL, Zhu, J, Zhang, B, Sullivan, PF, Chess, A, Purcell, SM, Shinobu, LA, Mangravite, LM, Toyoshiba, H, Gur, RE, Hahn, CG, Lewis, DA, Haroutunian, V, Peters, MA, Lipska, BK, Buxbaum, JD, Schadt, EE, Hirai, K, Roeder, K, Brennand, KJ, Katsanis, N, Domenici, E, Devlin, B & Sklar, P 2016, 'Gene expression elucidates functional impact of polygenic risk for schizophrenia', Nature Neuroscience, vol. 19, no. 11, pp. 1442-1453. https://doi.org/10.1038/nn.4399

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AU - Perumal, Thanneer M.

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KW - Multifactorial Inheritance/genetics

KW - Schizophrenia/genetics

KW - Gene Expression Regulation/genetics

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Gene expression elucidates functional impact of polygenic risk for schizophrenia

ASJC Scopus Subject Areas

Keywords

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