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Gasdermin-D-mediated epithelial-immune circuit synchronizes nutrient absorption and host defense in the small intestine

  • Qianzhou Yu
  • , Danlu Jiang
  • , Tianming Zhao
  • , Yuelin Guan
  • , Jian Zhang
  • , Dehang Yang
  • , Ruya Sun
  • , Weiwei Yu
  • , Zhen Wang
  • , Sheng Chen
  • , Mobai Li
  • , Tianyi Hu
  • , Qiqi Deng
  • , Xiaoyang Lu
  • , Yidong Yang
  • , Mengfei Chang
  • , Liheng Du
  • , Xue Zhang
  • , Zhexu Chi
  • , Di Wang

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)2226-2240.e7
JournalImmunity
Volume58
Issue number9
DOIs
StatePublished - Sep 9 2025
Externally publishedYes

ASJC Scopus Subject Areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Keywords

  • GSDMD
  • brush border assembly
  • enteritis
  • enterocyte
  • feeding pattern
  • host defense
  • intraepithelial γδ T lymphocytes
  • nutrient absorption
  • nutritional imbalance
  • the small intestine

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