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G2B: an optimized lentiviral vector with enhanced titer and β-globin expression for improved β-thalassemia gene therapy

  • Zhu Ying Gao
  • , Zhi Xue Yang
  • , Dong Hao Deng
  • , Feng Zhang
  • , Bing Yu
  • , Yang Yang Zhang
  • , Xiang Lv
  • , Yukio Nakamura
  • , An Gong
  • , Tao Cheng
  • , Jian Ping Zhang
  • , Xiao Bing Zhang

Research output: Contribution to journal › Article › peer-review

Original languageEnglish
Article numbere00253
Pages (from-to)1-12
Number of pages12
JournalBlood Science
Volume7
Issue number4
DOIs
StatePublished - 2025
Externally publishedYes

ASJC Scopus Subject Areas

  • Hematology

Keywords

  • Gene therapy
  • Hemoglobin subunit beta (HBB)
  • Hemoglobinopathies
  • Integration safety
  • Lentiviral vector
  • Locus control region
  • β-Thalassemia

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