Fragmentation and unpredictability of early-life experience in mental disorders

Tallie Z. Baram; Elysia P. Davis; Andre Obenaus; Curt A. Sandman; Steven L. Small; Ana Solodkin; Hal Stern

doi:10.1176/appi.ajp.2012.11091347

Fragmentation and unpredictability of early-life experience in mental disorders

Tallie Z. Baram
, Elysia P. Davis
, Andre Obenaus
, Curt A. Sandman
, Steven L. Small
, Ana Solodkin
, Hal Stern

Pediatrics

Research output: Contribution to journal › Review article › peer-review

Abstract

Maternal sensory signals in early life play a crucial role in programming the structure and function of the developing brain, promoting vulnerability or resilience to emotional and cognitive disorders. In rodent models of early-life stress, fragmentation and unpredictability of maternally derived sensory signals provoke persistent cognitive and emotional dysfunction in offspring. Similar variability and inconsistency of maternal signals during both gestation and early postnatal human life may influence development of emotional and cognitive functions, including those that underlie later depression and anxiety.

Original language	English
Pages (from-to)	907-915
Number of pages	9
Journal	American Journal of Psychiatry
Volume	169
Issue number	9
DOIs	https://doi.org/10.1176/appi.ajp.2012.11091347
State	Published - Aug 1 2012

ASJC Scopus Subject Areas

Psychiatry and Mental health

Keywords

Stress, Psychological/complications
Uncertainty
Animals
Maternal Behavior/psychology
Anxiety/etiology
Humans
Models, Animal
Depression/etiology
Mother-Child Relations
Brain/growth & development

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10.1176/appi.ajp.2012.11091347

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AU - Obenaus, Andre

AU - Sandman, Curt A.

AU - Small, Steven L.

AU - Solodkin, Ana

AU - Stern, Hal

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KW - Maternal Behavior/psychology

KW - Anxiety/etiology

KW - Humans

KW - Models, Animal

KW - Depression/etiology

KW - Mother-Child Relations

KW - Brain/growth & development

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Fragmentation and unpredictability of early-life experience in mental disorders

Abstract

ASJC Scopus Subject Areas

Keywords

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