Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic-ischemic injury in neonatal rats

Yong Li; Qingyi Ma; Shina Halavi; Katherine Concepcion; Richard E. Hartman; Andre Obenaus; Daliao Xiao; Lubo Zhang

doi:10.1016/j.expneurol.2015.10.007

Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic-ischemic injury in neonatal rats

Yong Li
, Qingyi Ma
, Shina Halavi
, Katherine Concepcion
, Richard E. Hartman
, Andre Obenaus
, Daliao Xiao
, Lubo Zhang

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Experimental Neurology
Volume	275
Issue number	Part 1
DOIs	https://doi.org/10.1016/j.expneurol.2015.10.007
State	Published - Jan 1 2016

ASJC Scopus Subject Areas

Neurology
Developmental Neuroscience

Keywords

5-aza-2'-deoxycytidine
DNA methylation
Fetal hypoxia
Hypoxia-inducible factor 1α
Hypoxic-ischemic brain injury
Animals, Newborn
Fetal Hypoxia/genetics
Matrix Metalloproteinase 2/metabolism
Disease Susceptibility
Matrix Metalloproteinase 9/metabolism
Rats
Male
Rats, Sprague-Dawley
Pregnancy
DNA Methylation
Hypoxia-Ischemia, Brain/genetics
Animals
Female
Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
Brain/metabolism

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10.1016/j.expneurol.2015.10.007

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title = "Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic-ischemic injury in neonatal rats",

keywords = "5-aza-2'-deoxycytidine, DNA methylation, Fetal hypoxia, Hypoxia-inducible factor 1α, Hypoxic-ischemic brain injury, Animals, Newborn, Fetal Hypoxia/genetics, Matrix Metalloproteinase 2/metabolism, Disease Susceptibility, Matrix Metalloproteinase 9/metabolism, Rats, Male, Rats, Sprague-Dawley, Pregnancy, DNA Methylation, Hypoxia-Ischemia, Brain/genetics, Animals, Female, Hypoxia-Inducible Factor 1, alpha Subunit/metabolism, Brain/metabolism",

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AU - Li, Yong

AU - Ma, Qingyi

AU - Halavi, Shina

AU - Concepcion, Katherine

AU - Hartman, Richard E.

AU - Obenaus, Andre

AU - Xiao, Daliao

AU - Zhang, Lubo

PY - 2016/1/1

Y1 - 2016/1/1

KW - 5-aza-2'-deoxycytidine

KW - DNA methylation

KW - Fetal hypoxia

KW - Hypoxia-inducible factor 1α

KW - Hypoxic-ischemic brain injury

KW - Animals, Newborn

KW - Fetal Hypoxia/genetics

KW - Matrix Metalloproteinase 2/metabolism

KW - Disease Susceptibility

KW - Matrix Metalloproteinase 9/metabolism

KW - Rats

KW - Male

KW - Rats, Sprague-Dawley

KW - Pregnancy

KW - DNA Methylation

KW - Hypoxia-Ischemia, Brain/genetics

KW - Animals

KW - Female

KW - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism

KW - Brain/metabolism

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SP - 1

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JO - Experimental Neurology

JF - Experimental Neurology

IS - Part 1

ER -

Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic-ischemic injury in neonatal rats

ASJC Scopus Subject Areas

Keywords

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