FBP1-Altered Carbohydrate Metabolism Reduces Leukemic Viability through Activating P53 and Modulating the Mitochondrial Quality Control System In Vitro

Yi Xu, Lily Tran, Janet Tang, Vinh Nguyen, Elisabeth Sewell, Jeffrey Xiao, Christopher Hino, Samiksha Wasnik, Olivia L. Francis-Boyle, Ke K. Zhang, Linglin Xie, Jiang F. Zhong, David J. Baylink, Chien Shing Chen, Mark E. Reeves, Huynh Cao

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number11387
JournalInternational Journal of Molecular Sciences
Volume23
Issue number19
DOIs
StatePublished - Oct 2022

ASJC Scopus Subject Areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Keywords

  • AML
  • FBP1
  • OXPHOS
  • P53
  • autophagy
  • glycolysis
  • metabolism
  • mitochondrion
  • mitophagy
  • Fructose-Bisphosphatase/genetics
  • Humans
  • Granulocyte Precursor Cells/metabolism
  • Electron Transport Complex IV/metabolism
  • fms-Like Tyrosine Kinase 3/genetics
  • Carbon Dioxide/metabolism
  • Mitochondria/drug effects
  • Carbohydrate Metabolism/drug effects
  • Cyclooxygenase 2/metabolism
  • Vitamin D/pharmacology
  • Leukemia, Myeloid, Acute/drug therapy
  • Fructose/pharmacology
  • Tumor Suppressor Protein p53/genetics
  • Vitamins/pharmacology
  • Disease Progression
  • Protein Kinases/metabolism
  • Cell Line, Tumor
  • Glycolysis
  • Apoptosis

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