Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangement

Yi Xu; Shengwen Calvin Li; Jeffrey Xiao; Qian Liu; Durga Cherukuri; Yan Liu; Saied Mirshahidi; Jane Xu; Xuelian Chen; Dadrastoussi Homa; Julian Olea; Kaijin Wu; Kevin R. Kelly; Fengzhu Sun; Ruihao Huang; Xiaoqi Wang; Qin Wen; Xi Zhang; Cristina M. Ghiuzeli; Esther Chong; Hisham Abdel-Azim; Mark E. Reeves; David J. Baylink; Huynh Cao; Jiang F. Zhong

doi:10.1016/j.drup.2024.101199

Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangement

Yi Xu
, Shengwen Calvin Li
, Jeffrey Xiao
, Qian Liu
, Durga Cherukuri
, Yan Liu
, Saied Mirshahidi
, Jane Xu
, Xuelian Chen
, Dadrastoussi Homa
, Julian Olea
, Kaijin Wu
, Kevin R. Kelly
, Fengzhu Sun
, Ruihao Huang
, Xiaoqi Wang
, Qin Wen
, Xi Zhang
, Cristina M. Ghiuzeli
, Esther Chong

Hisham Abdel-Azim, Mark E. Reeves, David J. Baylink, Huynh Cao, Jiang F. Zhong

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	101199
Journal	Drug Resistance Updates
Volume	79
DOIs	https://doi.org/10.1016/j.drup.2024.101199
State	Published - Mar 2025

ASJC Scopus Subject Areas

Oncology
Pharmacology
Infectious Diseases
Pharmacology (medical)
Cancer Research

Keywords

AFDN
AML
Chromosomal Translocation
KMT2A
RNA Variants
Refractory
Relapse
Unknown Gene Fusion

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10.1016/j.drup.2024.101199

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Xu, Y., Li, S. C., Xiao, J., Liu, Q., Cherukuri, D., Liu, Y., Mirshahidi, S., Xu, J., Chen, X., Homa, D., Olea, J., Wu, K., Kelly, K. R., Sun, F., Huang, R., Wang, X., Wen, Q., Zhang, X., Ghiuzeli, C. M., ... Zhong, J. F. (2025). Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangement. Drug Resistance Updates, 79, Article 101199. https://doi.org/10.1016/j.drup.2024.101199

Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangement. / Xu, Yi; Li, Shengwen Calvin; Xiao, Jeffrey et al.
In: Drug Resistance Updates, Vol. 79, 101199, 03.2025.

Research output: Contribution to journal › Article › peer-review

Xu, Y, Li, SC, Xiao, J, Liu, Q, Cherukuri, D, Liu, Y , Mirshahidi, S, Xu, J, Chen, X, Homa, D, Olea, J, Wu, K, Kelly, KR, Sun, F, Huang, R, Wang, X, Wen, Q, Zhang, X, Ghiuzeli, CM, Chong, E, Abdel-Azim, H , Reeves, ME , Baylink, DJ, Cao, H & Zhong, JF 2025, 'Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangement', Drug Resistance Updates, vol. 79, 101199. https://doi.org/10.1016/j.drup.2024.101199

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title = "Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangement",

keywords = "AFDN, AML, Chromosomal Translocation, KMT2A, RNA Variants, Refractory, Relapse, Unknown Gene Fusion",

author = "Yi Xu and Li, \{Shengwen Calvin\} and Jeffrey Xiao and Qian Liu and Durga Cherukuri and Yan Liu and Saied Mirshahidi and Jane Xu and Xuelian Chen and Dadrastoussi Homa and Julian Olea and Kaijin Wu and Kelly, \{Kevin R.\} and Fengzhu Sun and Ruihao Huang and Xiaoqi Wang and Qin Wen and Xi Zhang and Ghiuzeli, \{Cristina M.\} and Esther Chong and Hisham Abdel-Azim and Reeves, \{Mark E.\} and Baylink, \{David J.\} and Huynh Cao and Zhong, \{Jiang F.\}",

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doi = "10.1016/j.drup.2024.101199",

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AU - Li, Shengwen Calvin

AU - Xiao, Jeffrey

AU - Liu, Qian

AU - Cherukuri, Durga

AU - Liu, Yan

AU - Mirshahidi, Saied

AU - Xu, Jane

AU - Chen, Xuelian

AU - Homa, Dadrastoussi

AU - Olea, Julian

AU - Wu, Kaijin

AU - Kelly, Kevin R.

AU - Sun, Fengzhu

AU - Huang, Ruihao

AU - Wang, Xiaoqi

AU - Wen, Qin

AU - Zhang, Xi

AU - Ghiuzeli, Cristina M.

AU - Chong, Esther

AU - Abdel-Azim, Hisham

AU - Reeves, Mark E.

AU - Baylink, David J.

AU - Cao, Huynh

AU - Zhong, Jiang F.

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KW - KMT2A

KW - RNA Variants

KW - Refractory

KW - Relapse

KW - Unknown Gene Fusion

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ER -

Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangement

ASJC Scopus Subject Areas

Keywords

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