TY - JOUR
T1 - Evidence for basal distortion-product otoacoustic emission components
AU - Martin, Glen K.
AU - Stagner, Barden B.
AU - Lonsbury-Martin, Brenda L.
N1 - Funding Information:
This work was supported in part by the NIH (Grant No. DC000613) and the Veterans Administration (VA/RR&D Grant Nos. C449R and C6212L). The authors thank Alisa Nelson-Miller for technical assistance, and Dr. Paul F. Fahey, Dr. Jonathan H. Siegel, and Dr. Barbara K. Cone, and three anonymous reviewers for their helpful comments on the manuscript.
PY - 2010/5
Y1 - 2010/5
N2 - Distortion-product otoacoustic emissions (DPOAEs) were measured with traditional DP-grams and level/phase (L/P) maps in rabbits with either normal cochlear function or unique sound-induced cochlear losses that were characterized as either low-frequency or notched configurations. To demonstrate that emission generators distributed basal to the f2 primary-tone contribute, in general, to DPOAE levels and phases, a high-frequency interference tone (IT) was presented at 1/3 of an octave (oct) above the f 2 primary-tone, and DPOAEs were re-measured as "augmented" DP-grams (ADP-grams) and L/P maps. The vector difference between the control and augmented functions was then computed to derive residual DP-grams (RDP-grams) and L/P maps. The resulting RDP-grams and L/P maps, which described the DPOAEs removed by the IT, supported the notion that basal DPOAE components routinely contribute to the generation of standard measures of DPOAEs. Separate experiments demonstrated that these components could not be attributed to the effects of the 1/3-oct IT on f2, or DPOAEs generated by the addition of a third interfering tone. These basal components can "fill in" the lesion estimated by the commonly employed DP-gram. Thus, ADP-grams more accurately reveal the pattern of cochlear damage and may eventually lead to an improved DP-gram procedure.
AB - Distortion-product otoacoustic emissions (DPOAEs) were measured with traditional DP-grams and level/phase (L/P) maps in rabbits with either normal cochlear function or unique sound-induced cochlear losses that were characterized as either low-frequency or notched configurations. To demonstrate that emission generators distributed basal to the f2 primary-tone contribute, in general, to DPOAE levels and phases, a high-frequency interference tone (IT) was presented at 1/3 of an octave (oct) above the f 2 primary-tone, and DPOAEs were re-measured as "augmented" DP-grams (ADP-grams) and L/P maps. The vector difference between the control and augmented functions was then computed to derive residual DP-grams (RDP-grams) and L/P maps. The resulting RDP-grams and L/P maps, which described the DPOAEs removed by the IT, supported the notion that basal DPOAE components routinely contribute to the generation of standard measures of DPOAEs. Separate experiments demonstrated that these components could not be attributed to the effects of the 1/3-oct IT on f2, or DPOAEs generated by the addition of a third interfering tone. These basal components can "fill in" the lesion estimated by the commonly employed DP-gram. Thus, ADP-grams more accurately reveal the pattern of cochlear damage and may eventually lead to an improved DP-gram procedure.
UR - https://www.scopus.com/pages/publications/77956237602
UR - https://www.scopus.com/pages/publications/77956237602#tab=citedBy
U2 - 10.1121/1.3353121
DO - 10.1121/1.3353121
M3 - Article
C2 - 21117746
SN - 0001-4966
VL - 127
SP - 2955
EP - 2972
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
IS - 5
ER -