TY - JOUR
T1 - Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice
AU - Vidal, Olle
AU - Lindberg, Marie K.
AU - Hollberg, Karin
AU - Baylink, David J.
AU - Andersson, Göran
AU - Lubahn, Dennis B.
AU - Mohan, Subburaman
AU - Gustafsson, Jan Åke
AU - Ohlsson, Claes
PY - 2000/5/9
Y1 - 2000/5/9
N2 - Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly through aromatization of androgens into estrogen and, thereafter, through stimulation of estrogen receptors (ERs). The relative importance of ER subtypes in the regulation of the male skeleton was studied in ERα-knockout (ERKO), ERβ-knockout (BERKO), and double ERα/β-knockout (DERKO) mice. ERKO and DERKO, but not BERKO, demonstrated decreased longitudinal as well as radial skeletal growth associated with decreased serum levels of insulin-like growth factor I. Therefore, ERα, but not ERβ, mediates important effects of estrogen in the skeleton of male mice during growth and maturation.
AB - Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly through aromatization of androgens into estrogen and, thereafter, through stimulation of estrogen receptors (ERs). The relative importance of ER subtypes in the regulation of the male skeleton was studied in ERα-knockout (ERKO), ERβ-knockout (BERKO), and double ERα/β-knockout (DERKO) mice. ERKO and DERKO, but not BERKO, demonstrated decreased longitudinal as well as radial skeletal growth associated with decreased serum levels of insulin-like growth factor I. Therefore, ERα, but not ERβ, mediates important effects of estrogen in the skeleton of male mice during growth and maturation.
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U2 - 10.1073/pnas.97.10.5474
DO - 10.1073/pnas.97.10.5474
M3 - Article
C2 - 10805804
SN - 0027-8424
VL - 97
SP - 5474
EP - 5479
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 10
ER -