TY - JOUR
T1 - Erythropoietin Inhibits HIF-1α Expression via Upregulation of PHD-2 Transcription and Translation in an In Vitro Model of Hypoxia-Ischemia
AU - Souvenir, Rhonda
AU - Flores, Jerry J.
AU - Ostrowski, Robert P.
AU - Manaenko, Anatol
AU - Duris, Kamil
AU - Tang, Jiping
N1 - Hypoxia inducible factor (HIF)-1α is the central transcriptional factor for the regulation of oxygen-associated genes in response to hypoxia. Erythropoietin (EPO), a hematopoietic growth factor, increases oxygen availability during hypoxia/ischemia and is associated with neuroprotection following hypoxia-ischemia in laboratory models of stroke. However, EPO has failed to translate in a clinical setting.
PY - 2014/2
Y1 - 2014/2
KW - EPO
KW - HIF-1α
KW - OGD
KW - PHD-2
KW - Reactive Oxygen Species/metabolism
KW - Up-Regulation
KW - Rats
KW - Hypoxia-Inducible Factor-Proline Dioxygenases
KW - Neuroprotective Agents/pharmacology
KW - PC12 Cells
KW - Animals
KW - Procollagen-Proline Dioxygenase/biosynthesis
KW - Hypoxia-Ischemia, Brain/metabolism
KW - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
KW - Transcription, Genetic/drug effects
KW - Disease Models, Animal
KW - Erythropoietin/pharmacology
UR - https://www.scopus.com/pages/publications/84893749290
UR - https://www.scopus.com/pages/publications/84893749290#tab=citedBy
UR - https://www.mendeley.com/catalogue/c6887183-ec5d-35d3-ae8c-c3bccf07588b/
U2 - 10.1007/s12975-013-0312-z
DO - 10.1007/s12975-013-0312-z
M3 - Article
C2 - 24323731
SN - 1868-4483
VL - 5
SP - 118
EP - 127
JO - Translational Stroke Research
JF - Translational Stroke Research
IS - 1
ER -