TY - JOUR
T1 - Epiphyseal Plate Shear Strength in Rats Treated with a Diphosphonate
AU - Spengler, Dan M.
AU - Evans, Richard
AU - Baylink, David J.
AU - Spolek, Graig A.
N1 - Epiphyseal plate shear strength in rats treated with a diphosphonate.
PY - 1980/12
Y1 - 1980/12
N2 - Rats treated with a small dose (0.5 mg P/kg/day) of dichloromethylene diphosphonic acid (C12MDP) exhibited a marked increase in the shear strength of the proximal tibial epiphyseal plate with no suppression of longitudinal growth. Our results suggest that mechanisms in addition to the absorption of diphosphonate onto hydroxyapatite crystals account for the increase in epiphyseal plate shear strength noted in our experiment. In this regard, this diphosphonate could be valuable in studies of the normal determinants of epiphyseal plate shear strength. In addition, since C12MDP increased epiphyseal plate strength without suppressing longitudinal growth, the compound may eventually prove to be useful in the treatment of epiphyseal displacements in humans.
AB - Rats treated with a small dose (0.5 mg P/kg/day) of dichloromethylene diphosphonic acid (C12MDP) exhibited a marked increase in the shear strength of the proximal tibial epiphyseal plate with no suppression of longitudinal growth. Our results suggest that mechanisms in addition to the absorption of diphosphonate onto hydroxyapatite crystals account for the increase in epiphyseal plate shear strength noted in our experiment. In this regard, this diphosphonate could be valuable in studies of the normal determinants of epiphyseal plate shear strength. In addition, since C12MDP increased epiphyseal plate strength without suppressing longitudinal growth, the compound may eventually prove to be useful in the treatment of epiphyseal displacements in humans.
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U2 - 10.3181/00379727-165-41009
DO - 10.3181/00379727-165-41009
M3 - Article
C2 - 7465563
SN - 0037-9727
VL - 165
SP - 486
EP - 489
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 3
ER -