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Endogenous insulin signaling in the RPE contributes to the maintenance of rod photoreceptor function in diabetes

  • Matthew J. Tarchick
  • , Alecia H. Cutler
  • , Timothy D. Trobenter
  • , Michael R. Kozlowski
  • , Emily R. Makowski
  • , Nicholas Holoman
  • , Jianning Shao
  • , Bailey Shen
  • , Bela Anand-Apte
  • , Ivy S. Samuels

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)63-74
Number of pages12
JournalExperimental Eye Research
Volume180
DOIs
StatePublished - Mar 2019
Externally publishedYes

ASJC Scopus Subject Areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Keywords

  • Diabetic retinopathy
  • Insulin
  • Oxidative stress
  • Photoreceptor
  • Retinal pigment epithelium
  • Receptor, Insulin/genetics
  • Oxidative Stress
  • Retinal Pigment Epithelium/metabolism
  • Retinal Rod Photoreceptor Cells/physiology
  • Male
  • Signal Transduction/physiology
  • Diabetes Mellitus, Experimental/metabolism
  • Insulin/physiology
  • Retina/physiopathology
  • Real-Time Polymerase Chain Reaction
  • Electroretinography
  • Reactive Oxygen Species/metabolism
  • Blood Glucose/metabolism
  • Mice, Inbred C57BL
  • Diabetic Retinopathy/metabolism
  • Genetic Markers
  • Blotting, Western
  • Mice, Knockout
  • Animals
  • Mice

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