Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy

Jeremy Y. Huang; Brian Freed; Martin Hanus; Kelly Keefe; Ming Sum Ruby Chiang; Alexander Brezzani; Yongyi Luo; Yihang Li; Becky Lam; Stephanie Holley; Joseph Gans; Zuzana Dostalova; Buyun Tang; Clifford Phaneuf; Erin Teeple; Laura Parisi; Lilu Guo; Zhonglin Zhao; Sofia N. Kinton; Jacquelyn Dwyer; Sandrine Teixeira; Hong Ma; Gary Asmussen; Rajashree McLaren; Donghui Wang; Ann Baker; Craig S. Siegel; David Fink; Kristen Randall; Alexei Belenky; Suchitra Venugopal; Giorgio Gaglia; Jennifer Johnson; Dinesh S. Bangari; Bailin Zhang; Alexander Michel; Jonathan D. Proto; Alla Kloss; S. Pablo Sardi; Tatiana Gladysheva; Can Kayatekin

doi:10.1016/j.isci.2025.113248

Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy

Jeremy Y. Huang
, Brian Freed
, Martin Hanus
, Kelly Keefe
, Ming Sum Ruby Chiang
, Alexander Brezzani
, Yongyi Luo
, Yihang Li
, Becky Lam
, Stephanie Holley
, Joseph Gans
, Zuzana Dostalova
, Buyun Tang
, Clifford Phaneuf
, Erin Teeple
, Laura Parisi
, Lilu Guo
, Zhonglin Zhao
, Sofia N. Kinton
, Jacquelyn Dwyer

Sandrine Teixeira, Hong Ma, Gary Asmussen, Rajashree McLaren, Donghui Wang, Ann Baker, Craig S. Siegel, David Fink, Kristen Randall, Alexei Belenky, Suchitra Venugopal, Giorgio Gaglia, Jennifer Johnson, Dinesh S. Bangari, Bailin Zhang, Alexander Michel, Jonathan D. Proto, Alla Kloss, S. Pablo Sardi, Tatiana Gladysheva, Can Kayatekin

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	113248
Journal	iScience
Volume	28
Issue number	9
DOIs	https://doi.org/10.1016/j.isci.2025.113248
State	Published - Sep 19 2025
Externally published	Yes

ASJC Scopus Subject Areas

General

Keywords

Molecular interaction
Molecular mechanism of gene regulation
Molecular neuroscience
Transcriptomics

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10.1016/j.isci.2025.113248

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Huang, J. Y., Freed, B., Hanus, M., Keefe, K., Chiang, M. S. R., Brezzani, A., Luo, Y., Li, Y., Lam, B., Holley, S., Gans, J., Dostalova, Z., Tang, B., Phaneuf, C., Teeple, E., Parisi, L., Guo, L., Zhao, Z., Kinton, S. N., ... Kayatekin, C. (2025). Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy. iScience, 28(9), Article 113248. https://doi.org/10.1016/j.isci.2025.113248

Huang, JY, Freed, B, Hanus, M, Keefe, K, Chiang, MSR, Brezzani, A, Luo, Y, Li, Y, Lam, B, Holley, S, Gans, J, Dostalova, Z, Tang, B, Phaneuf, C, Teeple, E, Parisi, L, Guo, L, Zhao, Z, Kinton, SN, Dwyer, J, Teixeira, S, Ma, H, Asmussen, G, McLaren, R, Wang, D, Baker, A, Siegel, CS, Fink, D, Randall, K, Belenky, A, Venugopal, S, Gaglia, G, Johnson, J, Bangari, DS, Zhang, B, Michel, A, Proto, JD, Kloss, A, Sardi, SP, Gladysheva, T & Kayatekin, C 2025, 'Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy', iScience, vol. 28, no. 9, 113248. https://doi.org/10.1016/j.isci.2025.113248

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title = "Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy",

keywords = "Molecular interaction, Molecular mechanism of gene regulation, Molecular neuroscience, Transcriptomics",

author = "Huang, \{Jeremy Y.\} and Brian Freed and Martin Hanus and Kelly Keefe and Chiang, \{Ming Sum Ruby\} and Alexander Brezzani and Yongyi Luo and Yihang Li and Becky Lam and Stephanie Holley and Joseph Gans and Zuzana Dostalova and Buyun Tang and Clifford Phaneuf and Erin Teeple and Laura Parisi and Lilu Guo and Zhonglin Zhao and Kinton, \{Sofia N.\} and Jacquelyn Dwyer and Sandrine Teixeira and Hong Ma and Gary Asmussen and Rajashree McLaren and Donghui Wang and Ann Baker and Siegel, \{Craig S.\} and David Fink and Kristen Randall and Alexei Belenky and Suchitra Venugopal and Giorgio Gaglia and Jennifer Johnson and Bangari, \{Dinesh S.\} and Bailin Zhang and Alexander Michel and Proto, \{Jonathan D.\} and Alla Kloss and Sardi, \{S. Pablo\} and Tatiana Gladysheva and Can Kayatekin",

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AU - Huang, Jeremy Y.

AU - Freed, Brian

AU - Hanus, Martin

AU - Keefe, Kelly

AU - Chiang, Ming Sum Ruby

AU - Brezzani, Alexander

AU - Luo, Yongyi

AU - Li, Yihang

AU - Lam, Becky

AU - Holley, Stephanie

AU - Gans, Joseph

AU - Dostalova, Zuzana

AU - Tang, Buyun

AU - Phaneuf, Clifford

AU - Teeple, Erin

AU - Parisi, Laura

AU - Guo, Lilu

AU - Zhao, Zhonglin

AU - Kinton, Sofia N.

AU - Dwyer, Jacquelyn

AU - Teixeira, Sandrine

AU - Ma, Hong

AU - Asmussen, Gary

AU - McLaren, Rajashree

AU - Wang, Donghui

AU - Baker, Ann

AU - Siegel, Craig S.

AU - Fink, David

AU - Randall, Kristen

AU - Belenky, Alexei

AU - Venugopal, Suchitra

AU - Gaglia, Giorgio

AU - Johnson, Jennifer

AU - Bangari, Dinesh S.

AU - Zhang, Bailin

AU - Michel, Alexander

AU - Proto, Jonathan D.

AU - Kloss, Alla

AU - Sardi, S. Pablo

AU - Gladysheva, Tatiana

AU - Kayatekin, Can

PY - 2025/9/19

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KW - Molecular interaction

KW - Molecular mechanism of gene regulation

KW - Molecular neuroscience

KW - Transcriptomics

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JF - iScience

IS - 9

M1 - 113248

ER -

Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy

ASJC Scopus Subject Areas

Keywords

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