Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial

Mingyuan Zhang; Yanhang Gao; Fei Kong; Haibing Gao; Yongxiang Yi; Chao Wu; Yongning Xin; Sujun Zheng; Jiajie Lu; Tao Han; Yingren Zhao; Peng Hu; Xiaorong Mao; Qing Xie; Jie Zhang; Jinlin Hou; Zhiliang Gao; Jianqi Lian; Liang Chen; Jia Shang; Wen Xie; Mao Mu; Zhenjing Jin; Maorong Wang; Shide Lin; Huiying Rao; Dongliang Yang; Huanyu Gong; Lin Luo; Yunfu Chen; Yulei Zhuang; Yingjun Zhang; Robert G. Gish; Youwen Tan; Jiming Zhang; Junqi Niu

doi:10.1016/j.jinf.2025.106446

Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial

Mingyuan Zhang, Yanhang Gao, Fei Kong, Haibing Gao, Yongxiang Yi, Chao Wu, Yongning Xin, Sujun Zheng, Jiajie Lu, Tao Han, Yingren Zhao, Peng Hu, Xiaorong Mao, Qing Xie, Jie Zhang, Jinlin Hou, Zhiliang Gao, Jianqi Lian, Liang Chen, Jia ShangWen Xie, Mao Mu, Zhenjing Jin, Maorong Wang, Shide Lin, Huiying Rao, Dongliang Yang, Huanyu Gong, Lin Luo, Yunfu Chen, Yulei Zhuang, Yingjun Zhang, Robert G. Gish, Youwen Tan, Jiming Zhang, Junqi Niu

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	106446
Journal	Journal of Infection
Volume	90
Issue number	3
DOIs	https://doi.org/10.1016/j.jinf.2025.106446
State	Published - Mar 2025
Externally published	Yes

ASJC Scopus Subject Areas

Microbiology (medical)
Infectious Diseases

Keywords

Antiviral treatment
Capsid inhibitor
Chronic hepatitis B
GLS4
PgRNA

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Zhang, M., Gao, Y., Kong, F., Gao, H., Yi, Y., Wu, C., Xin, Y., Zheng, S., Lu, J., Han, T., Zhao, Y., Hu, P., Mao, X., Xie, Q., Zhang, J., Hou, J., Gao, Z., Lian, J., Chen, L., ... Niu, J. (2025). Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial. Journal of Infection, 90(3), Article 106446. https://doi.org/10.1016/j.jinf.2025.106446

Zhang, M, Gao, Y, Kong, F, Gao, H, Yi, Y, Wu, C, Xin, Y, Zheng, S, Lu, J, Han, T, Zhao, Y, Hu, P, Mao, X, Xie, Q, Zhang, J, Hou, J, Gao, Z, Lian, J, Chen, L, Shang, J, Xie, W, Mu, M, Jin, Z, Wang, M, Lin, S, Rao, H, Yang, D, Gong, H, Luo, L, Chen, Y, Zhuang, Y, Zhang, Y, Gish, RG, Tan, Y, Zhang, J & Niu, J 2025, 'Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial', Journal of Infection, vol. 90, no. 3, 106446. https://doi.org/10.1016/j.jinf.2025.106446

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title = "Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial",

keywords = "Antiviral treatment, Capsid inhibitor, Chronic hepatitis B, GLS4, PgRNA",

author = "Mingyuan Zhang and Yanhang Gao and Fei Kong and Haibing Gao and Yongxiang Yi and Chao Wu and Yongning Xin and Sujun Zheng and Jiajie Lu and Tao Han and Yingren Zhao and Peng Hu and Xiaorong Mao and Qing Xie and Jie Zhang and Jinlin Hou and Zhiliang Gao and Jianqi Lian and Liang Chen and Jia Shang and Wen Xie and Mao Mu and Zhenjing Jin and Maorong Wang and Shide Lin and Huiying Rao and Dongliang Yang and Huanyu Gong and Lin Luo and Yunfu Chen and Yulei Zhuang and Yingjun Zhang and Gish, {Robert G.} and Youwen Tan and Jiming Zhang and Junqi Niu",

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year = "2025",

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doi = "10.1016/j.jinf.2025.106446",

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T1 - Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients

T2 - A multicenter clinical trial

AU - Zhang, Mingyuan

AU - Gao, Yanhang

AU - Kong, Fei

AU - Gao, Haibing

AU - Yi, Yongxiang

AU - Wu, Chao

AU - Xin, Yongning

AU - Zheng, Sujun

AU - Lu, Jiajie

AU - Han, Tao

AU - Zhao, Yingren

AU - Hu, Peng

AU - Mao, Xiaorong

AU - Xie, Qing

AU - Zhang, Jie

AU - Hou, Jinlin

AU - Gao, Zhiliang

AU - Lian, Jianqi

AU - Chen, Liang

AU - Shang, Jia

AU - Xie, Wen

AU - Mu, Mao

AU - Jin, Zhenjing

AU - Wang, Maorong

AU - Lin, Shide

AU - Rao, Huiying

AU - Yang, Dongliang

AU - Gong, Huanyu

AU - Luo, Lin

AU - Chen, Yunfu

AU - Zhuang, Yulei

AU - Zhang, Yingjun

AU - Gish, Robert G.

AU - Tan, Youwen

AU - Zhang, Jiming

AU - Niu, Junqi

PY - 2025/3

Y1 - 2025/3

KW - Antiviral treatment

KW - Capsid inhibitor

KW - Chronic hepatitis B

KW - GLS4

KW - PgRNA

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Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial

ASJC Scopus Subject Areas

Keywords

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