Effects of the interaction between ferric iron and L‐dopa melanin on T1 and T2 relaxation times determined by magnetic resonance imaging

Jeffrey M. Tosk; Barbara A. Holshouser; Roland C. Aloia; David B. Hinshaw; Anton N. Hasso; James P. Macmurray; A. Douglas Will; Louis P. Bozzetti

doi:10.1002/mrm.1910260105

Effects of the interaction between ferric iron and L‐dopa melanin on T1 and T2 relaxation times determined by magnetic resonance imaging

Jeffrey M. Tosk, Barbara A. Holshouser, Roland C. Aloia, David B. Hinshaw, Anton N. Hasso, James P. Macmurray, A. Douglas Will, Louis P. Bozzetti

Radiology

Research output: Contribution to journal › Article › peer-review

Abstract

T1 and T2 relaxation times of agar phantoms containing L‐dopa melanin and Fe³⁺ were measured under MRI conditions. Fe³⁺ shortened T1 and T2 relaxation times. Melanin influenced relaxation times only in the presence of Fe³⁺; thus, contrast in MR images of the basal ganglia may depend upon levels of both paramagnetic iron and neuromelanin.

Original language	English
Pages (from-to)	40-45
Number of pages	6
Journal	Magnetic Resonance in Medicine
Volume	26
Issue number	1
DOIs	https://doi.org/10.1002/mrm.1910260105
State	Published - Jul 1992

ASJC Scopus Subject Areas

Radiology Nuclear Medicine and imaging

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title = "Effects of the interaction between ferric iron and L‐dopa melanin on T1 and T2 relaxation times determined by magnetic resonance imaging",

abstract = "T1 and T2 relaxation times of agar phantoms containing L‐dopa melanin and Fe3+ were measured under MRI conditions. Fe3+ shortened T1 and T2 relaxation times. Melanin influenced relaxation times only in the presence of Fe3+; thus, contrast in MR images of the basal ganglia may depend upon levels of both paramagnetic iron and neuromelanin.",

author = "Tosk, {Jeffrey M.} and Holshouser, {Barbara A.} and Aloia, {Roland C.} and Hinshaw, {David B.} and Hasso, {Anton N.} and Macmurray, {James P.} and Will, {A. Douglas} and Bozzetti, {Louis P.}",

note = "Magn Reson Med. 1992 Jul;26(1):40-5. Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.",

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T1 - Effects of the interaction between ferric iron and L‐dopa melanin on T1 and T2 relaxation times determined by magnetic resonance imaging

AU - Tosk, Jeffrey M.

AU - Holshouser, Barbara A.

AU - Aloia, Roland C.

AU - Hinshaw, David B.

AU - Hasso, Anton N.

AU - Macmurray, James P.

AU - Will, A. Douglas

AU - Bozzetti, Louis P.

N1 - Magn Reson Med. 1992 Jul;26(1):40-5. Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

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Y1 - 1992/7

N2 - T1 and T2 relaxation times of agar phantoms containing L‐dopa melanin and Fe3+ were measured under MRI conditions. Fe3+ shortened T1 and T2 relaxation times. Melanin influenced relaxation times only in the presence of Fe3+; thus, contrast in MR images of the basal ganglia may depend upon levels of both paramagnetic iron and neuromelanin.

AB - T1 and T2 relaxation times of agar phantoms containing L‐dopa melanin and Fe3+ were measured under MRI conditions. Fe3+ shortened T1 and T2 relaxation times. Melanin influenced relaxation times only in the presence of Fe3+; thus, contrast in MR images of the basal ganglia may depend upon levels of both paramagnetic iron and neuromelanin.

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Effects of the interaction between ferric iron and L‐dopa melanin on T1 and T2 relaxation times determined by magnetic resonance imaging

Abstract

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