@inbook{983ca4e9c032458fb862f9bc5ac180a7,
title = "Effects of Low-Dose Unfractionated Heparin Pretreatment on Early Brain Injury after Subarachnoid Hemorrhage in Mice.",
abstract = "Heparin is a pleiotropic drug that antagonizes many pathophysiological mechanisms. In this study, we evaluated whether heparin prevents early brain injury (EBI) after subarachnoid hemorrhage (SAH) in mice. SAH was induced by endovascular perforation in mice randomly assigned to sham-operated (n = 8), SAH + vehicle (n = 12), SAH + 10 U heparin pretreatment (n = 11), and SAH + 30 U heparin pretreatment (n = 14) groups. At 24 h post-SAH, severity of SAH, neurological scores, and brain water content were evaluated. Low-dose heparin pretreatment improved neurobehavioral function, and decreased brain edema in the ipsilateral cerebral hemisphere to the perforation side. High-dose heparin had a tendency for increased SAH, which obscured the neuroprotective effects by heparin. Low-dose heparin pretreatment may decrease the development of post-SAH EBI.",
keywords = "Severity of Illness Index, Heparin/administration \& dosage, Mortality, Apoptosis/drug effects, Punctures, Endovascular Procedures, Male, Random Allocation, Neuroprotective Agents/pharmacology, Brain Edema/physiopathology, Subarachnoid Hemorrhage/physiopathology, Brain/drug effects, Animals, Fibrinolytic Agents/administration \& dosage, Brain Injuries/physiopathology, Mice, Disease Models, Animal",
author = "Orhan Altay and Hidenori Suzuki and Yu Hasegawa and Mehmet Sorar and Han Chen and Jiping Tang and Zhang, \{John H.\}",
note = "Part of the Acta Neurochirurgica Supplement book series (NEUROCHIRURGICA, volume 121) Heparin is a pleiotropic drug that antagonizes many pathophysiological mechanisms. In this study, we evaluated whether heparin prevents early brain injury (EBI) after subarachnoid hemorrhage (SAH) in mice.",
year = "2016",
month = jan,
day = "1",
doi = "10.1007/978-3-319-18497-5\_22",
language = "American English",
isbn = "978-3-319-18496-8",
series = "Acta Neurochirurgica, Supplementum",
publisher = "Springer Cham",
pages = "127--130",
booktitle = "Brain Edema XVI",
}