TY - JOUR
T1 - Effect of treatment with parathyroid extract on bone parameters and metabolism of 3H-25-hydroxyvitamin D3 in Hypocalcemic Thyroparathyroidectomized Rats
AU - Rader, J. I.
AU - Turner, R. T.
AU - Howard, G. A.
AU - Baylink, D. J.
N1 - Funding Information:
Acknowledgements: Supported in part by NIH grants AG 00299 and DE 02600, and the Research Service of the Veterans Administration.
PY - 1979
Y1 - 1979
N2 - Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.
AB - Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.
KW - 1,25-dihydroxyvitamin D
KW - 25-hydroxyvitamin D
KW - Mineral metabolism
KW - Parathyroid extract
KW - Quantitative histology
KW - Thyroparathyroidectomy
UR - https://www.scopus.com/pages/publications/49249153110
UR - https://www.scopus.com/pages/publications/49249153110#tab=citedBy
U2 - 10.1016/0221-8747(79)90025-0
DO - 10.1016/0221-8747(79)90025-0
M3 - Article
SN - 0221-8747
VL - 1
SP - 313
EP - 317
JO - Metabolic Bone Disease and Related Research
JF - Metabolic Bone Disease and Related Research
IS - 4
ER -