Effect of the calcium entry blocker verapamil on renal ischemia

J. L. Woolley; G. R. Barker; W. K. Jacobsen; G. A. Gingrich; S. C. Stewart; B. A. Briggs; R. D. Martin; R. A. Melashenko

doi:10.1097/00003246-198801000-00009

Effect of the calcium entry blocker verapamil on renal ischemia

J. L. Woolley
, G. R. Barker
, W. K. Jacobsen
, G. A. Gingrich
, S. C. Stewart
, B. A. Briggs
, R. D. Martin
, R. A. Melashenko

Research output: Contribution to journal › Article › peer-review

Abstract

The ability of the calcium entry blocker verapamil to ameliorate the effects of renal ischemia was studied in ten sheep. Postanesthesia, bilateral cutaneous ureterostomies were placed in each sheep to facilitate urine collection and analysis. Both kidneys were made ischemic for one hour by occluding each renal artery. However, immediately before occlusion of the right renal artery, 0.05 mg/kg of verapamil was injected into the artery. Comparison of urinary creatinine excretion and urine volume for 72 h after reversal of ischemia demonstrated that those kidneys pretreated with verapamil had greater functional preservation (p < .05). In this study, verapamil appeared to provide protection against renal damage after an ischemic insult.

Original language	English
Pages (from-to)	48-51
Number of pages	4
Journal	Critical Care Medicine
Volume	16
Issue number	1
DOIs	https://doi.org/10.1097/00003246-198801000-00009
State	Published - Jan 1988

ASJC Scopus Subject Areas

Critical Care and Intensive Care Medicine

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AU - Jacobsen, W. K.

AU - Gingrich, G. A.

AU - Stewart, S. C.

AU - Briggs, B. A.

AU - Martin, R. D.

AU - Melashenko, R. A.

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AB - The ability of the calcium entry blocker verapamil to ameliorate the effects of renal ischemia was studied in ten sheep. Postanesthesia, bilateral cutaneous ureterostomies were placed in each sheep to facilitate urine collection and analysis. Both kidneys were made ischemic for one hour by occluding each renal artery. However, immediately before occlusion of the right renal artery, 0.05 mg/kg of verapamil was injected into the artery. Comparison of urinary creatinine excretion and urine volume for 72 h after reversal of ischemia demonstrated that those kidneys pretreated with verapamil had greater functional preservation (p < .05). In this study, verapamil appeared to provide protection against renal damage after an ischemic insult.

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Effect of the calcium entry blocker verapamil on renal ischemia

Abstract

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