Effect of the antiviral drug, cytosine arabinoside, on the developing nervous system

Stephen Ashwal; Milton Finegold; Irving Fish; Gleb Budzilovich; Philip A. Brunell

doi:10.1203/00006450-197412000-00006

Effect of the antiviral drug, cytosine arabinoside, on the developing nervous system

Stephen Ashwal, Milton Finegold, Irving Fish, Gleb Budzilovich, Philip A. Brunell

Research output: Contribution to journal › Article › peer-review

Abstract

Cytosine arabinoside (which is used to treat congenital viral infections) produced neurologic and retinal damage in infant mice. Station and gait abnormalities could be related to hypoplasia and marked microscopic changes in the cerebellum of treated animals. These, as well as microscopic changes in the retina, appeared to be irreversible. The damage produced appeared to result from destruction of primordial cells during a critical period of differentiation. Speculation the potential for producing neurologic and other damage by treatment with DNA inhibitors during this period of rapid growth must be considered when contemplating the use of these DNA inhibitors for treatment of congenital virus infections.

Original language	English
Pages (from-to)	945-950
Number of pages	6
Journal	Pediatric Research
Volume	8
Issue number	12
DOIs	https://doi.org/10.1203/00006450-197412000-00006
State	Published - Dec 1974

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health

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abstract = "Cytosine arabinoside (which is used to treat congenital viral infections) produced neurologic and retinal damage in infant mice. Station and gait abnormalities could be related to hypoplasia and marked microscopic changes in the cerebellum of treated animals. These, as well as microscopic changes in the retina, appeared to be irreversible. The damage produced appeared to result from destruction of primordial cells during a critical period of differentiation. Speculation the potential for producing neurologic and other damage by treatment with DNA inhibitors during this period of rapid growth must be considered when contemplating the use of these DNA inhibitors for treatment of congenital virus infections.",

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AU - Brunell, Philip A.

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AB - Cytosine arabinoside (which is used to treat congenital viral infections) produced neurologic and retinal damage in infant mice. Station and gait abnormalities could be related to hypoplasia and marked microscopic changes in the cerebellum of treated animals. These, as well as microscopic changes in the retina, appeared to be irreversible. The damage produced appeared to result from destruction of primordial cells during a critical period of differentiation. Speculation the potential for producing neurologic and other damage by treatment with DNA inhibitors during this period of rapid growth must be considered when contemplating the use of these DNA inhibitors for treatment of congenital virus infections.

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Effect of the antiviral drug, cytosine arabinoside, on the developing nervous system

Abstract

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