TY - JOUR
T1 - Effect of inhibitors of leukotriene and/or platelet activating factor on killed H. influenzae induced experimental otitis media with effusion
AU - Jung, Timothy T.K.
AU - Park, Seong Kook
AU - Rhee, Chong Ku
N1 - Funding Information:
This study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, the NIH Guide for the Care and Use of Laboratory Animals , and the animal Welfare Act (7 U.S.C. et seq.); the animal use protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of Loma Linda University and J.L. Pettis Memorial Veterans Hospital. This study was supported by the Deafness Research Foundation.
PY - 2004/1
Y1 - 2004/1
N2 - Our previous studies have shown that leukotriene (LT) and platelet activating factor (PAF) are important inflammatory mediators (IMs) in the pathogenesis of otitis media with effusion (OME). The purpose of this study was to determine the effect of a LT-inhibitor and/or PAF-antagonist on experimentally induced OME by killed H. influenzae in chinchillas. LT-inhibitor SCH-37224 and/or PAF-antagonist WEB-2170 were systematically administered, each separately or in combination, 2h prior and then at regular intervals after the injection of killed H. influenzae into the superior bullae. After 48h, OME was completely prevented in the combination group while it was only partially prevented in the other two separately treated groups. Animals in the control group all developed OME. Findings of this study suggest the importance of LT and PAF in the pathogenesis of OME and the usefulness of their blockers in the prevention of OME suggesting possible future therapeutic implication. © 2003 Elsevier Ireland Ltd. All rights reserved.
AB - Our previous studies have shown that leukotriene (LT) and platelet activating factor (PAF) are important inflammatory mediators (IMs) in the pathogenesis of otitis media with effusion (OME). The purpose of this study was to determine the effect of a LT-inhibitor and/or PAF-antagonist on experimentally induced OME by killed H. influenzae in chinchillas. LT-inhibitor SCH-37224 and/or PAF-antagonist WEB-2170 were systematically administered, each separately or in combination, 2h prior and then at regular intervals after the injection of killed H. influenzae into the superior bullae. After 48h, OME was completely prevented in the combination group while it was only partially prevented in the other two separately treated groups. Animals in the control group all developed OME. Findings of this study suggest the importance of LT and PAF in the pathogenesis of OME and the usefulness of their blockers in the prevention of OME suggesting possible future therapeutic implication. © 2003 Elsevier Ireland Ltd. All rights reserved.
KW - Animal model
KW - Killed H. influenzae
KW - Leukotriene inhibitor
KW - Otitis media with effusion
KW - Platelet activating factor antagonist
UR - https://www.scopus.com/pages/publications/0347625941
UR - https://www.scopus.com/pages/publications/0347625941#tab=citedBy
UR - https://www.mendeley.com/catalogue/cb6fb88f-2a69-3e46-b9de-76249f4518f7/
U2 - 10.1016/j.ijporl.2003.09.006
DO - 10.1016/j.ijporl.2003.09.006
M3 - Article
SN - 0165-5876
VL - 68
SP - 57
EP - 63
JO - International Journal of Pediatric Otorhinolaryngology
JF - International Journal of Pediatric Otorhinolaryngology
IS - 1
ER -