TY - JOUR
T1 - Effect of corticosteroids on serum antinuclear antibodies in man
AU - Weisbart, Richard H.
AU - Colburn, Keith
N1 - Funding Information:
We thank Amelia Kacena, Grace Chan and Judy Johnson for technical assistance, and Satien Poo-prasert M.D. and Xavier Caro M. D. for providing serum samples. This work was supported by Public Health Services grant CA-30280 and CA-32737
PY - 1984/10
Y1 - 1984/10
N2 - The effect of prednisone on serum levels of IgG antibodies to viral and bacterial antigens was measured and compared to its effect on IgG antibodies to nuclear antigens in 8 patients with systemic lupus erythematosus. Prednisone at 15-80 mg/day (mean 55 mg/day) for 14-30 days (mean 19 days) lowered the serum IgG by an average of 22% (p<0.005). An even greater reduction in IgG antinuclear antibodies occurred (mean 43%, p<0.001) including responses to double stranded DNA, single stranded DNA, and the nucleosides, adenosine, guanosine, cytidine and thymine riboside. In contrast, there was no alteration in serum IgG antibody levels to influenza virus vaccine and pneumococcal vaccine antigens. These results suggest that prednisone has a selective effect on the expression of autoimmunity which may, in part, be responsible for its clinical efficacy in systemic lupus erythematosus.
AB - The effect of prednisone on serum levels of IgG antibodies to viral and bacterial antigens was measured and compared to its effect on IgG antibodies to nuclear antigens in 8 patients with systemic lupus erythematosus. Prednisone at 15-80 mg/day (mean 55 mg/day) for 14-30 days (mean 19 days) lowered the serum IgG by an average of 22% (p<0.005). An even greater reduction in IgG antinuclear antibodies occurred (mean 43%, p<0.001) including responses to double stranded DNA, single stranded DNA, and the nucleosides, adenosine, guanosine, cytidine and thymine riboside. In contrast, there was no alteration in serum IgG antibody levels to influenza virus vaccine and pneumococcal vaccine antigens. These results suggest that prednisone has a selective effect on the expression of autoimmunity which may, in part, be responsible for its clinical efficacy in systemic lupus erythematosus.
KW - Antinuclear antibodies
KW - Corticosteroids
KW - Systemic lupus erythematosus
UR - https://www.scopus.com/pages/publications/0021659612
UR - https://www.scopus.com/pages/publications/0021659612#tab=citedBy
U2 - 10.1016/0162-3109(84)90048-1
DO - 10.1016/0162-3109(84)90048-1
M3 - Article
C2 - 6334672
SN - 0162-3109
VL - 8
SP - 97
EP - 101
JO - Immunopharmacology
JF - Immunopharmacology
IS - 2
ER -